Mitochondrial dynamics plays important roles in pancreas beta cell and hepatocytes to regulate glucose and lipid metabolism.

线粒体在有氧产生ATP的氧化磷酸化，以及在各种细胞过程，如细胞凋亡和Ca 2+信号中起着重要作用。线粒体形态通过响应细胞能量需求、分化或致病条件而发生的平衡融合和分裂过程动态变化。为了阐明线粒体分裂在体内胰腺β细胞和肝细胞中的作用，我们使用Cre-loxP系统分别破坏胰腺β细胞（Drp 1betaKO）和肝细胞（Drp 1 LiKO）中的Drp 1。Drp 1betaKO小鼠对葡萄糖和显性糖尿病的反应显示出胰岛素分泌缺陷。在高脂饮食下，Drp 1 LiKO小鼠发生非酒精性脂肪性肝炎，内质网应激标志物显著升高。总体而言，线粒体动力学在胰腺β细胞和肝细胞中起重要作用，以满足能量需求。

Mitochondria have essential roles in the aerobic generation of ATP by oxidative phosphorylation, as well as in variety of cellular processes such as apoptosis and Ca2+ signaling. The mitochondrial morphology changes dynamically by a balanced fusion and fission processes that occur in response to cellular energy demands, differentiation or pathogenic conditions. In order to clarify the roles of mitochondrial fission in pancreatic beta cells and hepatocytes in vivo, we used a Cre-loxP system to disrupt Drp1 in pancreatic beta cells (Drp1betaKO) and hepatocytes (Drp1LiKO), respectively. Drp1betaKO mice showed defective insulin secretion in response to glucose and overt diabetes. Upon high fat diet, Drp1LiKO mice developed non-alcoholic steatohepatitis with marked elevation of the endoplasmic reticulum stress markers.Collectively, mitochondrial dynamics plays important roles in pancreas beta cell and hepatocytes to meet energy demand.