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Detection for miRNA dysregulation in CML

Detection for miRNA dysregulation in CML
检测 CML 中的 miRNA 失调
批准号:
23591365
负责人:
TAKAHASHI Naoto
金额:
$3.49万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
To detect specific miRNA in cancer stem cell of chromic myelogenious leukemia (CML), we established CML mice (B6) which can develop CML. We got cancer stem cells from B6 mice and examined miRNA expression from KLS population. We found that several miRNA were up-or down regulated in these mice. For instance, down regulation of miR-203,miR-200c, miR-26,miR-21,miR-2105, and miR-181. In this time we are examining targets of these miRNAs. We identified Bmi-1 is possible target of miR-200c in CML stem cells. And we fort her demonstrated that bortezomib was effective for diminishing CML stem cells by targeting both Bmi-1 and miR-200c.
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DOI: 10.1371/journal.pone.0056954
发表时间: 2013
期刊: PloS one
影响因子: 3.7
作者: [Nara M, Teshima K, Watanabe A, Ito M, Iwamoto K, Kitabayashi A, Kume M, Hatano Y, Takahashi N, Iida S, Sawada K, Tagawa H]
通讯作者: Tagawa H
DOI: 10.1016/j.exphem.2011.12.002
发表时间: 2012-04-01
期刊: EXPERIMENTAL HEMATOLOGY
影响因子: 2.6
作者: [Liu, Jiajia, Guo, Yong-Mei, Sawada, Kenichi]
通讯作者: Sawada, Kenichi
DOI: 10.1182/blood-2011-06-361907
发表时间: 2012-01-26
期刊: BLOOD
影响因子: 20.3
作者: [Ubukawa, Kumi, Guo, Yong-Mei, Sawada, Kenichi]
通讯作者: Sawada, Kenichi
The attainment of doctoral degrees in law in Germany by Japanese students in the Meiji period and their significance for legal history
  • 批准号:
    17K03334
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $1.83万
  • 财政年份:
    2017
  • 负责人:
    TAKAHASHI Naoto
  • 依托单位:
Immunological analysis of neonatal diseases by profile assays of cytokines, cytokine-related genes and transcription factors
The Formation of the Modern Criminal Law and the Legal Education in Germany, Especially from the End of the 18th Century to the First Half of the 19th Century.
  • 批准号:
    19730013
  • 项目类别:
    Grant-in-Aid for Young Scientists (B)
  • 资助金额:
    $0.88万
  • 财政年份:
    2007
  • 负责人:
    TAKAHASHI Naoto
  • 依托单位:
Immunological investigation for pathophysiology of infectious diseases induced by bacterial superantigens in neonates and childhood
  • 批准号:
    16591050
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $2.37万
  • 财政年份:
    2004
  • 负责人:
    TAKAHASHI Naoto
  • 依托单位:
国内基金
海外基金
基于外泌体miRNA标志物的老年乳腺癌化疗毒性预测模型构建及护理干预路径优化
  • 批准号:
    2026JJ80561
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    孟火娟
  • 依托单位:
血清外泌体中高表达的miRNA-148a在阿尔茨海默病进展中的作用机制研究
M2型巨噬细胞来源外泌体中miRNA-21下调KLF5抑制心肌梗死中脂毒性的作用及机制研究
  • 批准号:
    2026JJ81356
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    彭漪
  • 依托单位:
靶向CDH1 调控相关的miRNA 在早发性胃癌中的作用机制及诊断价值研究
  • 批准号:
    ZCLMRY26H2003
  • 项目类别:
    省市级项目
  • 资助金额:
    --
  • 批准年份:
    2026
  • 负责人:
    张毅敏
  • 依托单位: