Possible involvements of proton-sensing receptors in alleric airway inflammation and fibrosis

卵巢癌G蛋白偶联受体1（OGR 1）被细胞外质子刺激导致G蛋白活化和随后的细胞功能。我们发现，OGR 1缺陷小鼠对哮喘的主要特征，包括气道嗜酸性粒细胞增多，气道高反应性和小鼠过敏性哮喘模型中的杯状细胞化生具有抵抗力。另一方面，单独的酸性pH诱导结缔组织生长因子（CTGF）的大量产生，并增强转化生长因子-β诱导的CTGF mRNA和蛋白表达，通过OGR 1在人气道平滑肌细胞。我们的研究结果表明，OGR 1在过敏性气道炎症和气道重塑的发病机制中发挥重要作用，OGR 1可能是哮喘的治疗靶点。

Ovarian cancer G protein-coupled receptor 1 (OGR1) stimulation by extracellular protons causes the activation of G proteins and subsequent cellular functions. We showed that OGR1-deficient mice are resistant to the cardinal features of asthma, including airway eosinophilia, airway hyperresponsiveness, and goblet cell metaplasia in a murine allergic asthma model. On the other hand, acidic pH alone induced a substantial production of connective tissue growth factor (CTGF) and enhanced transforming growth factor-beta-induced CTGF mRNA and protein expression through OGR1 in human airway smooth muscle cells. Our results suggest that OGR1 plays an important role in the pathogenesis of allergic airway inflammtion and airway remodelling and OGR1 may be a therapeutic target of asthma.