Possible involvements of proton-sensing receptors in alleric airway inflammation and fibrosis

卵巢癌G蛋白偶联受体1(OGR1)受细胞外质子的刺激，引起G蛋白的激活和随后的细胞功能。在小鼠过敏性哮喘模型中，我们发现OGR1缺陷小鼠对哮喘的基本特征具有抵抗力，包括气道嗜酸性粒细胞增多、气道高反应性和杯状细胞化生。另一方面，酸性pH单独诱导人气道平滑肌细胞产生大量结缔组织生长因子(CTGF)，并通过OGR1增强转化生长因子-β诱导的CTGF mRNA和蛋白表达。我们的结果提示OGR1在过敏性气道炎和气道重塑的发病机制中起重要作用，OGR1可能是哮喘的治疗靶点。

Ovarian cancer G protein-coupled receptor 1 (OGR1) stimulation by extracellular protons causes the activation of G proteins and subsequent cellular functions. We showed that OGR1-deficient mice are resistant to the cardinal features of asthma, including airway eosinophilia, airway hyperresponsiveness, and goblet cell metaplasia in a murine allergic asthma model. On the other hand, acidic pH alone induced a substantial production of connective tissue growth factor (CTGF) and enhanced transforming growth factor-beta-induced CTGF mRNA and protein expression through OGR1 in human airway smooth muscle cells. Our results suggest that OGR1 plays an important role in the pathogenesis of allergic airway inflammtion and airway remodelling and OGR1 may be a therapeutic target of asthma.