The creation of novel treatment and testing for developmental disorders based on the mechanisms of a developmental disorder model accompanying social abnormality.

首席研究员报告说，大脑中的丝氨酸蛋白酶motopsin的缺失增强了社会行为。在本研究中，我们分析了motopsin和sez-6（被鉴定为motopsin结合蛋白）转染神经母细胞瘤细胞后对细胞形态的影响。结果表明，这些蛋白酶协同调节神经元细胞的形态。此外，我们发现大脑中的丝氨酸蛋白酶通常调节社会行为的可能性，因为缺乏组织纤溶酶原激活物（大脑中的另一种蛋白酶）的小鼠在行为测试中表现出增强的社会焦虑。

The principal investigator has reported that the loss of motopsin, a serine protease in the brain, enhances social behaviors. In this research, we analyzed the effects of motopsin and sez-6, which was identified as a motopsin-binding protein, on the cell morphology when they were transfected in neuroblastoma cells. The results suggested that these proteinases coordinately modulate the morphology of neuronal cells. Further, we showed a possibility that serine proteases in the brain ordinarily modulate social behaviors, since the mice lacking tissue plasminogen activator, another protease in the brain, showed enhanced social anxiety in behavioral tests.