The creation of novel treatment and testing for developmental disorders based on the mechanisms of a developmental disorder model accompanying social abnormality.

首席研究人员报告说，大脑中一种丝氨酸蛋白酶Motopsin的丢失会增强社交行为。在这项研究中，我们分析了Motopsin和SEZ-6(一种被鉴定为Motopsin结合蛋白的蛋白)在转染神经母细胞瘤细胞时对细胞形态的影响。结果提示，这些蛋白水解酶对神经细胞的形态有协同调节作用。此外，我们还证明了大脑中的丝氨酸蛋白酶正常调节社交行为的可能性，因为缺乏组织纤溶酶原激活剂的小鼠在行为测试中表现出更强的社交焦虑。

The principal investigator has reported that the loss of motopsin, a serine protease in the brain, enhances social behaviors. In this research, we analyzed the effects of motopsin and sez-6, which was identified as a motopsin-binding protein, on the cell morphology when they were transfected in neuroblastoma cells. The results suggested that these proteinases coordinately modulate the morphology of neuronal cells. Further, we showed a possibility that serine proteases in the brain ordinarily modulate social behaviors, since the mice lacking tissue plasminogen activator, another protease in the brain, showed enhanced social anxiety in behavioral tests.