Study on the epileptogenesis in child-onset intractable epilepsy

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In order to clarify the epileptogenesis in child-onset intractable epilepsy, we performed the immunohistochemical analysis in autopsy brains, and the examination of amino acids and neurotransmitter metabolites in the cerebrospinal fluid from patients, simultaneously. We succeeded in disclosing the abnormal expression of voltage-dependent sodium channels and/or the facilitation of autophagy in the cerebral cortex in cases of West syndrome, and the disturbed metabolism of amino acid and monoamines in patients with infantile convulsion.In addition, we established the screening method of anti-neuronal antibodies in patients with subacute autoimmune encephalitis, which became to occur frequently in Japan, and explored the mechanisms of generation of refractory epilepsy in such encephalitis.We believe that these data will give us a clue for developing new treatments in patients with refractory epilepsy.