Exhaustive analysis about the onset etiology of the pediatric inflammatory diseases by using the proteome method

本研究的目的是利用蛋白质组学方法对高细胞因子血症患者急性期和恢复期的血清蛋白进行分析，该方法是一种综合性的蛋白质分析方法。在本研究中，应阐明以下发现。(1)炎症的机制-细胞因子风暴的原因探寻-最终，我们可以在各种炎症性疾病中鉴定出本研究中的原始蛋白质，目前计划增加标本数量并进行附加测试。(2)炎症细胞因子和细胞因子的功能“细胞因子风暴”患者的病情：我们分析了炎症细胞因子的表达、作用机制等多种蛋白，并完成了通用蛋白的鉴定（正在投稿英文期刊）。（3）儿童时期出现的细胞因子风暴：我们可以阐明是什么导致了儿童在低龄时的“炎症”，以及为什么会引发细胞因子风暴。这项研究得到了有趣的结果。

The purposes in this study were to analyze serum proteins for both acute and convalescent phases in the patients with hypercytokinemia using the proteome method which was comprehensive protein analytical method, In this study, the following findings should be elucidated.(1) The mechanism of inflammation -Search of the cause of the cytokine storm-Finally, we could identify original protein in this study in various inflammatory diseases, and we are planning to increase the number of the specimens and to perform the addition tests now.(2) A function of inflammatory cytokine and condition of a patient of " cytokine storm: We analyzed various proteins about expression, action mechanism of inflammatory cytokine, and accomplish to identify universal protein (under submission to English journal).(3) Cytokine storm to be seen in childhood: We could elucidate what caused "inflammation" of children at a low age and why could a cytokine storm raise. We got the interesting results in this study.