Exhaustive analysis about the onset etiology of the pediatric inflammatory diseases by using the proteome method

利用蛋白质组学方法详尽分析小儿炎症性疾病的发病病因

• 批准号: 23591545
• 负责人: MORI MASAAKI
• 金额: $ 3.24万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591545/
• 关键词: サイトカイン; 小児炎症性疾患; プロテーム解析; ｻｲﾄｶｲﾝ; 小児炎症疾患

The purposes in this study were to analyze serum proteins for both acute and convalescent phases in the patients with hypercytokinemia using the proteome method which was comprehensive protein analytical method, In this study, the following findings should be elucidated.(1) The mechanism of inflammation -Search of the cause of the cytokine storm-Finally, we could identify original protein in this study in various inflammatory diseases, and we are planning to increase the number of the specimens and to perform the addition tests now.(2) A function of inflammatory cytokine and condition of a patient of " cytokine storm: We analyzed various proteins about expression, action mechanism of inflammatory cytokine, and accomplish to identify universal protein (under submission to English journal).(3) Cytokine storm to be seen in childhood: We could elucidate what caused "inflammation" of children at a low age and why could a cytokine storm raise. We got the interesting results in this study.

本研究采用蛋白质组学方法对高细胞因子血症患者急性期和恢复期的血清蛋白质进行了分析。(1)炎症的机制-细胞因子风暴的原因的搜索-最后，我们可以在各种炎症性疾病中识别本研究中的原始蛋白质，我们现在计划增加样本数量并进行附加测试。(2)炎性细胞因子的功能和“细胞因子风暴”患者的状况：我们分析了各种蛋白质的表达，炎性细胞因子的作用机制，并完成了通用蛋白的鉴定（提交给英文期刊）。(3)细胞因子风暴在儿童时期出现：我们可以阐明是什么导致了儿童在低年龄时的“炎症”，以及为什么细胞因子风暴会上升。我们在这项研究中得到了有趣的结果。

项目成果

A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness.

• DOI: 10.1186/1471-2334-11-168
• 发表时间: 2011-06-10
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Fujitsuka A;Tsukagoshi H;Arakawa M;Goto-Sugai K;Ryo A;Okayama Y;Mizuta K;Nishina A;Yoshizumi M;Kaburagi Y;Noda M;Tashiro M;Okabe N;Mori M;Yokota S;Kimura H
• 通讯作者: Kimura H

ガイドラインセッションII 「領域別」:小児領域.

指南第二部分“按区域”：儿科区域。

• 发表时间: 2013
• 作者: Fujiki A;Imamura T;Furutani A;Hatano W;Asai D;Hirashima Y;Miyachi M;Tamura S;Tsuchiya K;Iehara T;Ishida H;Yoshihara T;Hosoi H.;森 雅亮
• 通讯作者: 森 雅亮

Association of IRF5 Polymorphisms with Susceptibility to Hemophagocytic Lymphohistiocytosis in Children

• DOI: 10.1007/s10875-011-9583-x
• 发表时间: 2011-09
• 期刊: Journal of Clinical Immunology
• 影响因子: 9.1
• 作者: M. Yanagimachi;H. Goto;T. Miyamae;Keisuke Kadota;T. Imagawa;M. Mori;Hidenori Sato;R. Yanagisawa;T. Kaneko;S. Morita;E. Ishii;S. Yokota

既存治療で効果不十分な多関節に活動性を有する若年性特発性関節炎(JIA)患者にエタネルセプトを長期投与したときの安全性および有効性

对现有治疗没有充分反应的多关节活动性幼年特发性关节炎 (JIA) 患者长期服用依那西普的安全性和有效性

• 发表时间: 2012
• 作者: 坂本謙一;今村俊彦;矢野未央;吉田秀樹;藤木 敦;平嶋良章;細井 創;宮村 能子;森雅亮
• 通讯作者: 森雅亮

Plasma exchange therapy for cases refractory to IVIG treatment–from analysis in the multi-institutions in Japan -

IVIG治疗难治性病例的血浆交换治疗——来自日本多机构的分析——

• 发表时间: 2012
• 作者: Ogura M;Urabe M;Akimoto T;Onishi A;Ito C;Ito T;Tsukahara T;Mizukami H;Kume A;Muto S;Kusano E;and Ozawa K.;坂本謙一,今村俊彦,矢野未央,吉田秀樹,藤木敦,平嶋良章,細井創;近藤直実 松井永子;Mori M.
• 通讯作者: Mori M.