Urinary angiotensinogen as a novel biomarker in pediatric patients with chronic glomerulonephritis

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We tested hypothesis that measurements of urinary angiotensinogen level provide a specific diagnostic test for identifying patients with activated infrarenal renin- angiotensin system (RAS) in pediatric IgA nephropathy. As the results, urinary angiotensinogen levels were significantly decreased after RAS blockade treatment, accompanied by the magnitude of renal injury. Additionally, urinary angiotensinogen levels were positively correlated with the level of renal injury. These data indicated that the urinary angiotensinogen is a useful biomarker of infrarenal RAS activation, which is associated with renal injury during RAS blockade treatment in pediatric IgAN patients.