Urinary angiotensinogen as a novel biomarker in pediatric patients with chronic glomerulonephritis

尿血管紧张素原作为慢性肾小球肾炎儿科患者的新型生物标志物

• 批准号: 23591569
• 负责人: URUSHIHARA Maki
• 金额: $ 3.33万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591569/
• 关键词: 腎炎; アンジオテンシノーゲン; バイオマーカー; 慢性腎炎

We tested hypothesis that measurements of urinary angiotensinogen level provide a specific diagnostic test for identifying patients with activated infrarenal renin- angiotensin system (RAS) in pediatric IgA nephropathy. As the results, urinary angiotensinogen levels were significantly decreased after RAS blockade treatment, accompanied by the magnitude of renal injury. Additionally, urinary angiotensinogen levels were positively correlated with the level of renal injury. These data indicated that the urinary angiotensinogen is a useful biomarker of infrarenal RAS activation, which is associated with renal injury during RAS blockade treatment in pediatric IgAN patients.

我们检验了一个假设，即尿血管紧张素原水平的测量提供了一个特定的诊断测试，以确定患者的肾下激活的肾素-血管紧张素系统（RAS）的儿童伊加肾病。结果显示，RAS阻断治疗后尿血管紧张素原水平显著降低，并伴有肾损伤程度。此外，尿血管紧张素原水平与肾损伤程度呈正相关。这些数据表明，尿血管紧张素原是一个有用的生物标志物肾下RAS激活，这是与肾损伤在RAS阻断治疗儿童IgA肾病患者。

项目成果

小児IgA腎症における尿中アンジオテンシノーゲンと腎内RAS活性化および糸球体病変の関係

小儿IgA肾病尿血管紧张素原、肾内RAS激活与肾小球病变的关系

• 发表时间: 2015
• 作者: 漆原 真樹 永井 隆;木下 ゆき子;Jamba Ariunbold;近藤 秀治;小堀 浩幸;香美 祥二
• 通讯作者: 香美 祥二