Evaluation of oxidative stress in children with non-alcoholic steatohepatitis

非酒精性脂肪性肝炎患儿氧化应激的评价

• 批准号: 23591589
• 负责人: TAMAI HIROSHI
• 金额: $ 3.33万
• 依托单位: Osaka Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591589/
• 关键词: 非アルコール性脂肪性肝疾患; 非アルコール性脂肪肝炎; 抗酸化剤; 脂肪性肝疾患

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disorder in developed countries, and its incidence is increasing in adults and children. As an antioxidant, vitamin E is effective in treatment of NAFLD, although the mechanism is still unclear. Methionine-choline deficient (MCD) rats used as an experimental model of NAFLD were fed a vitamin E-enriched diet. In the MCD rats, vitamin E treatment altered the hepatic alpha-tocopherol-related protein expression, which may affect the alpha-tocopherol status in the liver and reduce lipid peroxidation.

非酒精性脂肪性肝病(NAFLD)是发达国家最常见的肝病，其发病率在成人和儿童中呈上升趋势。作为一种抗氧化剂，维生素E在治疗NAFLD方面是有效的，尽管其机制尚不清楚。以蛋氨酸-胆碱缺乏症(MCD)大鼠作为NAFLD的实验模型，饲喂维生素E强化饲料。在MCD大鼠中，维生素E治疗改变了肝脏α-生育酚相关蛋白的表达，这可能影响了肝脏中α-生育酚的状态，减少了脂质过氧化。

项目成果

Retinol Status and Expression of Retinol-Related Proteins in Methionine-Choline Deficient Rats

• DOI: 10.3177/jnsv.60.78
• 发表时间: 2014-04-01
• 期刊: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
• 影响因子: 1.6
• 作者: Miyazaki, Hiroshi;Takitani, Kimitaka;Tamai, Hiroshi
• 通讯作者: Tamai, Hiroshi

α-Tocopherol Status and Expression of α-Tocopherol Transfer Protein in Type 2 Diabetic Goto-Kakizaki Rats

• DOI: 10.3177/jnsv.59.64
• 发表时间: 2013-02-01
• 期刊: JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
• 影响因子: 1.6
• 作者: Miyazaki, Hiroshi;Takitani, Kimitaka;Tamai, Hiroshi
• 通讯作者: Tamai, Hiroshi

ビタミンE研究の進歩

维生素E研究进展

• 发表时间: 2013
• 作者: 渡邉誠;深澤隆治;勝部康弘;小川俊一;他;徳山研一;玉井浩
• 通讯作者: 玉井浩

Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy.

妊娠期慢性乙型肝炎急性加重接受拉米夫定、干扰素-β和泼尼松龙三联疗法治疗的病例。

• DOI: 10.1111/j.1872-034x.2012.01077.x
• 发表时间: 2013-04
• 期刊: Hepatology research : the official journal of the Japan Society of Hepatology
• 作者: Koh M;Shinohara J;Hongo Y;Okazaki T;Takitani K;Tamai H
• 通讯作者: Tamai H

GNB3 C825T polymorphism is associated with postural tachycardia syndrome in children.

GNB3 C825T 多态性与儿童体位性心动过速综合征相关。

• DOI: 10.1111/j.1442-200x.2012.03707.x
• 发表时间: 2012
• 期刊: Pediatr Int.
• 作者: Nakao R;Tanaka H;Takitani K;Kajiura M;Okamoto N;Kanbara Y;Tamai H.
• 通讯作者: Tamai H.