The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models

调节性 B 细胞在系统性硬化症和细胞因子诱导的纤维化模型中的作用

• 批准号: 23591640
• 负责人: TAKEHARA KAZUHIKO
• 金额: $ 3.49万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591640/
• 关键词: IL-10; B細胞; 全身性強皮症; 制御性B細胞

Regulatory B cells that produce IL-10 are an important role for negative immune response. The frequency of regulatory B cell in PBMC from 28 systemic sclerosis patients and 24 healthy controls were examined. The frequency of regulatory B cell in PBMC was decreased in systemic sclerosis patients compared to healthy controls. Next, the role of regulatory B cell in the cytokine induced fibrosis models was examined using lack of regulatory B cell mice (CD19 deficient mice). There was no significant difference between wild type mice and CD19 deficient mice.These results suggest that decreased regulatory B cell may contribute to pathogenesis of systemic sclerosis, although regulatory B cell does not affect the development of fibrosis.

产生IL-10的调节性B细胞在负性免疫应答中起重要作用。检测了28例系统性硬化症患者和24例健康对照者外周血单个核细胞（PBMC）中调节性B细胞的频率。与健康对照组相比，系统性硬化症患者PBMC中调节性B细胞的频率降低。接下来，使用缺乏调节性B细胞的小鼠（CD 19缺陷小鼠）检查调节性B细胞在细胞因子诱导的纤维化模型中的作用。这些结果表明，调节性B细胞的减少可能参与了系统性硬化症的发病机制，尽管调节性B细胞并不影响纤维化的发展。

项目成果

Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease

• DOI: 10.1182/blood-2012-11-465658
• 发表时间: 2013-04-18
• 期刊: BLOOD
• 影响因子: 20.3
• 作者: Doanh Le Huu;Matsushita, Takashi;Fujimoto, Manabu
• 通讯作者: Fujimoto, Manabu

アトピー性皮膚炎診療が楽しくなる!Q&Aで考える実践治療

通过问答，让特应性皮炎治疗变得有趣！

• 发表时间: 2011
• 作者: Ayuko Kikusawa;Masahiro Oka;Hideki Shimizu,1 Mariko Tsujimoto;Yumiko Marui;Shusaku Yokogawa; Yasufumi Kita; Makoto Kunisada;and Chikako Nishigori;波多野豊;竹原和彦
• 通讯作者: 竹原和彦

Serum adhesion molecule levels as prognostic markers in patients with early systemic sclerosis: a multicentre, prospective, observational study.

• DOI: 10.1371/journal.pone.0088150
• 发表时间: 2014
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Hasegawa M;Asano Y;Endo H;Fujimoto M;Goto D;Ihn H;Inoue K;Ishikawa O;Kawaguchi Y;Kuwana M;Ogawa F;Takahashi H;Tanaka S;Sato S;Takehara K
• 通讯作者: Takehara K

アトピー性皮膚炎診療が楽しくなる！Q＆Aで考える実践治療

特应性皮炎治疗变得有趣！

• 发表时间: 2011
• 作者: Hatano Y;Elias PM;Crumrine D;Feingold KR;Katagiri K;Fujiwara S;竹原和彦
• 通讯作者: 竹原和彦

High incidence of pulmonary arterial hypertension in systemic sclerosis patients with anti-centriole autoantibodies

• DOI: 10.3109/14397595.2013.844296
• 发表时间: 2015-01-01
• 期刊: MODERN RHEUMATOLOGY
• 影响因子: 2.2
• 作者: Hamaguchi, Yasuhito;Matsushita, Takashi;Fujimoto, Manabu
• 通讯作者: Fujimoto, Manabu