The role of regulatory B cell in systemic sclerosis and cytokine-induced fibrosis models

产生IL-10的调节性B细胞在负性免疫应答中起重要作用。本文检测了28例系统性硬化症患者和24例健康对照者PBMC中调节性B细胞的频率。与健康对照相比，系统性硬化症患者PBMC中调节性B细胞的频率降低。接下来，使用缺乏调节性B细胞小鼠（CD19缺陷小鼠）检测调节性B细胞在细胞因子诱导纤维化模型中的作用。野生型小鼠与CD19缺陷小鼠之间无显著差异。这些结果表明，尽管调节性B细胞不影响纤维化的发展，但调节性B细胞的减少可能有助于系统性硬化症的发病机制。

Regulatory B cells that produce IL-10 are an important role for negative immune response. The frequency of regulatory B cell in PBMC from 28 systemic sclerosis patients and 24 healthy controls were examined. The frequency of regulatory B cell in PBMC was decreased in systemic sclerosis patients compared to healthy controls. Next, the role of regulatory B cell in the cytokine induced fibrosis models was examined using lack of regulatory B cell mice (CD19 deficient mice). There was no significant difference between wild type mice and CD19 deficient mice.These results suggest that decreased regulatory B cell may contribute to pathogenesis of systemic sclerosis, although regulatory B cell does not affect the development of fibrosis.