Pathological bases of schizophrenia-like psychotic disorders in the elderly

我们研究了包括嗜银颗粒病（AGD）在内的神经退行性疾病与晚发性精神分裂症样精神障碍（LOSD;发病年龄>40岁）之间的关系。在所有LOSD病例中（与对照组相比），路易体病（LBD）、AGD和皮质基底节变性（CBD）的频率分别为26.1%（11.3%）、21.7%（8.5%）和4.3%（0.0%）。LOSD患者LBD、AGD和CBD的总频率显著高于正常对照组。在≥ 65岁的LOSD患者中，LBD和AGD的发生率分别为36.4%（19.4%）和36.4%（8.3%），且LOSD患者AGD的发生率显著高于正常对照组。鉴于这些发现，AGD可能与LOSD的发生有关。

We examined the relationship between neurodegenerative diseases including argyrophilic grain disease (AGD) and late-onset schizophrenia-like psychotic disorders (LOSD; onset age>40 years of age). In all LOSD cases (compared to controls), the frequencies of Lewy body disease (LBD), AGD, and corticobasal degeneration (CBD) were 26.1% (11.3%), 21.7% (8.5%), and 4.3% (0.0%), respectively. The total frequency of LBD, AGD, and CBD was significantly higher in LOSD cases than in normal controls. In LOSD patients whose onset occurred at >65 years of age, the frequencies of LBD and AGD were 36.4% (19.4%) and 36.4% (8.3%), respectively, and AGD was significantly more frequent in LOSD patients than in normal controls. Given these findings, AGD may be associated with the occurrence of LOSD.