A study on autonomic nervous system activities during sleep and the prognosis of major depression

睡眠期间自主神经系统活动与重度抑郁症预后的研究

• 批准号: 23591726
• 负责人: MIYAOKA Hitoshi
• 金额: $ 1.83万
• 依托单位: Kitasato University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591726/
• 关键词: うつ病; 自律神経; 予後

Previous studies have shown that incidence of depression or its severity is associated with autonomic nerves system activities. But no study on autonomic nerves system activities as a marker for prognosis of depression has been performed yet. This study aims to examine to what extent changes in the autonomic nervous system during sleep in the early treatment can predict the prognosis of depression treatment, by using major depression patients who meet DSM-4 diagnostic criteria and by measuring autonomic nervous system activities during their sleep. In the antidepressant efficacy cases, it was speculated that parasympathetic components during sleep may improve from the early stage, but this study shows a tendency that parasympathetic component during sleep is inhibited.

以往的研究表明抑郁症的发生率或严重程度与自主神经系统活动有关。但目前还没有将自主神经系统活动作为抑郁症预后指标的研究。本研究以符合DSM-4诊断标准的抑郁症患者为研究对象，通过测定其睡眠时自主神经系统的活动，探讨在抑郁症治疗的早期，自主神经系统在睡眠时的变化在多大程度上可以预测抑郁症治疗的预后。在抗抑郁疗效的情况下，据推测，睡眠中的副交感神经成分可能会从早期开始改善，但本研究显示，睡眠中的副交感神经成分受到抑制的趋势。

项目成果

Intelligence or years of education: which is better correlated with memory function in normal elderly Japanese subjects?

• DOI: 10.1111/j.1479-8301.2012.00408.x
• 发表时间: 2013-03
• 期刊: Psychogeriatrics
• 影响因子: 2
• 作者: N. Murayama;E. Iseki;H. Tagaya;K. Ota;K. Kasanuki;H. Fujishiro;H. Arai;Kiyoshi Sato