The Relationship between Visceral Fat, Adipoctokines and colorectal neoplasma development evaluated by computed tomography (CT) colonography

通过计算机断层扫描（CT）结肠成像评估内脏脂肪、脂肪因子与结直肠肿瘤发展之间的关系

• 批准号: 23591805
• 负责人: MATSUMOTO Hiroshi
• 金额: $ 3.41万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591805/
• 关键词: 大腸CT検査; CTコロノグラフィー; 内臓脂肪型肥満; 生活習慣病; アデイポカイン; 大腸腫瘍; 内臓型肥満; アディポサイトカイン; 大腸3次元解析; ＣＴコロノグラフィー; 内臓脂肪; 肥満

• Obesity, visceral fat is associated with increased risks for colorectal neoplasm, cancer (CRC) and adenomatous polyp (polyp). CT colonography(CTC) is adopted as a new examination tool for colorectal cancer screening. Evaluate the relationship among colorectal neoplasm, visceral adiposity and adipocytokines. 123 patients who underwent both colonoscopy and CTC were enrolled in this study. We classified three patient groups: no lesion (NL; n=40), Adenomatous polyp (Polyp; n=41), early colorectal cancer (eCRC; n=21), and advanced CRC (aCRC; n=21) groups. Total adipose area (TAA), TAA index in both polyp and CRC groups were significantly higher than that in the NL. CT colonography could not be an only useful examination to diagnose colorectal neoplasms, but also to evaluated the visceral obesity, risk factor of polyp, at the same time.

• 肥胖、内脏脂肪与结直肠肿瘤、癌症(CRC) 和腺瘤性息肉(息肉) 的风险增加有关。 CT结肠成像（CTC）作为结直肠癌筛查的新检查工具。评估结直肠肿瘤、内脏肥胖和脂肪细胞因子之间的关系。本研究纳入了 123 名接受结肠镜检查和 CTC 的患者。我们将患者分为三个组：无病变组（NL；n=40）、腺瘤性息肉组（Polyp；n=41）、早期结直肠癌组（eCRC；n=21）和晚期结直肠癌组（aCRC；n=21）。息肉组和CRC组的总脂肪面积(TAA)、TAA指数均显着高于NL组。 CT结肠造影不仅可以作为诊断结直肠肿瘤的唯一有用检查，同时也可以评估内脏肥胖这一息肉的危险因素。