Mechanism elucidation of proton beam specific cellular response for radiation therapy

研究了质子束和X射线在人体细胞诱变和突变谱上的差异。质子和X射线对细胞的杀伤作用基本相同，但突变频率不同，质子辐照细胞的HPRT突变频率低于X射线照射的细胞。此外，质子束和X射线诱变后外显子的缺失谱也不同。这些发现表明，即使质子束和X射线的RBE值相似，在诱变方面也存在着定量和定性的差异。

The differences in mutation induction and mutation spectrum between proton beams and X-rays in human cells were investigated. Cell killing effect was almost the same between proton beams and X-rays, while a difference in mutation frequency was observed and the frequency of hprt mutation of cells irradiated with proton beams was lower than that of cells irradiated with X-rays. Furthermore, the deletion spectrum of exons was different in induced mutants between proton beams and X-rays. These findings suggest that there are quantitative and qualitative differences in mutation induction between proton beams and X-rays even if the RBE values are similar.