Mechanism elucidation of proton beam specific cellular response for radiation therapy

质子束放射治疗特异性细胞反应的机制阐明

• 批准号: 23591854
• 负责人: HATASHITA masanori
• 金额: $ 3.33万
• 依托单位: The Wakasa Wan Energy Research Center
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591854/
• 关键词: 量子ビーム; イオンビーム; 突然変異; 放射線感受性

The differences in mutation induction and mutation spectrum between proton beams and X-rays in human cells were investigated. Cell killing effect was almost the same between proton beams and X-rays, while a difference in mutation frequency was observed and the frequency of hprt mutation of cells irradiated with proton beams was lower than that of cells irradiated with X-rays. Furthermore, the deletion spectrum of exons was different in induced mutants between proton beams and X-rays. These findings suggest that there are quantitative and qualitative differences in mutation induction between proton beams and X-rays even if the RBE values are similar.

研究了质子束和X射线在人体细胞诱变和突变谱上的差异。质子和X射线对细胞的杀伤作用基本相同，但突变频率不同，质子辐照细胞的HPRT突变频率低于X射线照射的细胞。此外，质子束和X射线诱变后外显子的缺失谱也不同。这些发现表明，即使质子束和X射线的RBE值相似，在诱变方面也存在着定量和定性的差异。

项目成果

Nitric Oxide is a Key Molecule Serving as a Bridge between Radiation-Induced Bystander and Adaptive Responses

• DOI: 10.2174/1874467211104020126
• 发表时间: 2011-05
• 期刊: Current Molecular Pharmacology
• 影响因子: 2.7
• 作者: H. Matsumoto;M. Tomita;Kensuke Otsuka;M. Hatashita;N. Hamada