Development of cisplutium binding hialulonic acid gel as a novel intraperitoneal chemotherapeutic agent for peritoneal dissemination of gastric cancer

在这项研究中，我们旨在生产一种适用于腹腔化疗的新型生物材料。将水溶性顺铂加入原位交联透明质酸凝胶中，延长顺铂在腹腔内的滞留时间。我们可以证明顺铂从HA凝胶中连续释放超过5天。在小鼠腹膜播散模型的体内实验中，含1 mg/kg顺铂的透明质酸凝胶可降低腹膜播散性结核的总重量，但相同剂量顺铂的腹腔注射无抗肿瘤作用。原位交联透明质酸凝胶作为一种新型给药系统，可用于亲水性抗癌药物的腹腔给药。

In this study, we aimed to produce novel biological material which is suitable for intraperitoneal (i.p.) chemotherapy. Water-soluble cisplatinum was incorporated in in-situ cross-linkage hyaluronic acid (HA) gel to prolong the intraperitoneal retention of cisplatinum. We could show that cisplatinum was released from HA gel continuously for more than 5 days. In vivo assay using mouse peritoneal dissemination model, HA gel with 1 mg/kg cisplatinum decreased the total weight of peritoneal disseminated nodulus, but the i.p. administration of the same amount of cisplatinum did not show anti-tumor effect. In situ cross linkage HA gel is useful for i.p. administration of hydrophilic anti-cancer drugs as a novel drug delivery system.