Targeting therapy of Epithelial-Mesenchymal transition about human gastric cancer.

人胃癌上皮间质转化的靶向治疗。

• 批准号: 23591949
• 负责人: SASAKO Mitsuru
• 金额: $ 3.33万
• 依托单位: Hyogo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591949/
• 关键词: 線維芽細胞; 胃がん; 微小環境; EMT; Ephrin; 腹膜転移; CAFs; 胃十二指腸外科学

We established primary cultured fibroblast library isolated from gastric cancer patients. Fibroblasts modified invasiveness and EMT status of cancer cell. Proteome analysis, RNA microarray indicated over-expression of Ephrin receptor family in cancer stromal cells. Ephrin receptor and related pathway might be good targets of cancer-microenvironment about gastric cancer.

我们建立了原代培养的胃癌成纤维细胞文库。成纤维细胞改变了癌细胞的侵袭性和EMT状态。蛋白质组分析、RNA微阵列检测结果表明，肿瘤间质细胞中存在Epherin受体家族的过度表达。肾上腺素受体及其相关通路可能是研究胃癌微环境的良好靶点。