Targeting therapy of Epithelial-Mesenchymal transition about human gastric cancer.
Targeting therapy of Epithelial-Mesenchymal transition about human gastric cancer.
批准号:
23591949
负责人:
SASAKO Mitsuru
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
我们建立了原代培养的胃癌患者成纤维细胞库。成纤维细胞改变癌细胞的侵袭性和EMT状态。蛋白质组学分析、RNA微阵列分析表明Ephrin受体家族在肿瘤间质细胞中过表达。Ephrin受体及其相关通路可能是胃癌微环境的良好靶点。
英文摘要
We established primary cultured fibroblast library isolated from gastric cancer patients. Fibroblasts modified invasiveness and EMT status of cancer cell. Proteome analysis, RNA microarray indicated over-expression of Ephrin receptor family in cancer stromal cells. Ephrin receptor and related pathway might be good targets of cancer-microenvironment about gastric cancer.
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会议论文
Clinicopatological analysis of carcinogenesis of gastric carcinoma
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批准号:20591580
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2008
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负责人:SASAKO Mitsuru
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依托单位:
海外基金