Clinicopatological analysis of carcinogenesis of gastric carcinoma

胃癌发生机制的临床病理学分析

• 批准号: 20591580
• 负责人: SASAKO Mitsuru
• 金额: $ 2.91万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591580/
• 关键词: 癌幹細胞; ピロリ菌; 食道; 胃癌; hedgehog情報伝達系; シチジデアミナーゼ; 分化; 食道・胃癌; polycomb群

PurposeWe focused to prognosis of gastric cancer patients, and the expression of AID/Epithelial-mesenchymal transition related gene in gastric cancer tissue.Results1. We established a database of gastric cancer patients in Hyogo Collage of Medicine, which contains clinical factor, pathological factors, the expression of AID/EMT related genes.2. Clinicopathological features of gastric cancer are pathological heterogeneity and invasiveness. We performed quantitative real-time RT-PCR array for AID/EMT (84genes) using resected gastric cancer tissue in our hospital. EMT related gene was significantly related to invasiveness of diffuse type of cancer.

目的探讨胃癌患者的预后及AID/Epithelial-Mesenchymal Transition相关基因在胃癌组织中的表达。建立了兵库医学院胃癌患者数据库，包含临床因素、病理因素、AID/EMT相关基因的表达。胃癌的临床病理特征是病理异质性和侵袭性。我们采用实时荧光定量RT-PCR芯片技术对我院胃癌组织中的AID/EMT（84个基因）进行了检测。EMT相关基因与弥漫型胃癌的侵袭性显著相关。

项目成果

for the Japan Clinical Oncology Group : Functional outcomes after extended surgery for gastric cancer.

日本临床肿瘤学组：胃癌扩大手术后的功能结果。

• 发表时间: 2011
• 期刊: British Journal of Surgery 98
• 作者: Y.Kurokawa;M.Sasako;T.Sano;T.Shibata;S.Ito;A.Nashimoto;A.Kurita;T.Kinoshita
• 通讯作者: T.Kinoshita

Hedgehog signal activation in oesophageal cancer patients undergoing neoadjuvant chemoradiotherapy.

• DOI: 10.1038/sj.bjc.6604361
• 发表时间: 2008-05-20
• 期刊: British journal of cancer
• 影响因子: 8.8
• 作者: Yoshikawa R;Nakano Y;Tao L;Koishi K;Matsumoto T;Sasako M;Tsujimura T;Hashimoto-Tamaoki T;Fujiwara Y
• 通讯作者: Fujiwara Y

Association of stem cell marker BMI1 expression with early recurrence and poor prognosis in esophageal cancer patients after neoadjuvant chemoradiotherapy

干细胞标志物BMI1表达与食管癌新辅助放化疗后早期复发及不良预后的关系

• 发表时间: 2009
• 作者: Fujiwara;et al.
• 通讯作者: et al.

Expression of uPAR mRNA in peripheral blood is a favourite marker for metastasis in gastric cancer cases

• DOI: 10.1038/sj.bjc.6604806
• 发表时间: 2009-01-13
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Kita, Y.;Fukagawa, T.;Mori, M.
• 通讯作者: Mori, M.

胃癌浸潤における上皮間葉細胞分化転換EMTの解析

上皮间质细胞转分化EMT在胃癌侵袭中的分析

• 发表时间: 2011
• 作者: 菊池正二郎;竹村雅至;小石健二;堀高明;松本友寛;海辺展明;山下英孝;花山寛之;辻村亨;笹子三津留
• 通讯作者: 笹子三津留