The effect of prophylactic preoperative endoscopic transpapillary pancreatic stenting on clinically significant pancreatic fistula following distal pancreatectomy

术前预防性内镜下经乳头胰腺支架置入术对远端胰腺切除术后有临床意义的胰瘘的影响

• 批准号: 23592008
• 负责人: MATSUMOTO Ippei
• 金额: $ 1.58万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592008/
• 关键词: 膵管ステント; 尾側膵切除術; 術後膵液瘻; 膵体尾部切除術; 膵体尾部切叙述; 膵液瘻; 膵切除術

Postoperative pancreatic fistula (PF) causes major morbidity after distal pancreatectomy (DP). The purpose of this prospective study is to determine whether prophylactic preoperative endoscopic transpapillary pancreatic stenting (EPS) reduces PF formation after DP. Fifteen patients underwent DP following EPS. Clinically significant PF (ISGPF [the International Study Group on Pancreatic Fistula] classification Grade B and C) occurred in 4 (26.7%). We decided to terminate the study after internal analysis because our study design required 35 patients with estimated PF rate 10%.Prophylactic preoperative EPS dose not reduce PF after DP.

胰体尾切除术后胰瘘的发生率很高。这项前瞻性研究的目的是确定预防性术前内镜下经乳头胰腺支架植入术（EPS）是否减少DP后PF的形成。15例患者在EPS后接受DP。4例（26.7%）发生具有临床意义的PF（ISGPF [国际胰瘘研究组]分类B和C级）。我们决定在内部分析后终止研究，因为我们的研究设计需要35例估计PF发生率10%的患者，预防性术前EPS不会降低DP后的PF。