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Detection of aberrant expression of microRNAs and development of new diagnostics and treatment in lung cancer

Detection of aberrant expression of microRNAs and development of new diagnostics and treatment in lung cancer
肺癌中 microRNA 异常表达的检测以及新诊断和治疗方法的开发
批准号：
23592061
负责人：
MIYOSHI Shinichiro
金额：
$3.24万
依托单位：
Okayama University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
项目状态：
已结题
起止时间：
2011 至 2013
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592061/
关键词：
原発性肺癌マイクロRNA

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中文摘要
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英文摘要
We detected that expression of miR-34b/c and miR-200c was inhibited in lung cancer. miR-34b/c was more frequently inhibited by methylation in small cell lung cancer. We detected that induction of miR-34b/c showed anti-tumor effect in malignant pleural mesothelioma in vivo. As for miR-200c, its expression was maintained in EGFR-mutant lung cancer cell lines and it was inhibited in EGFR-mutant lung cancer cell line with acquired resistance to EGFR-tyrosine kinase inhibitor (TKI). In addition, epithelial to mesenchymal transition (EMT) was observed in that TKI-resistant cell line. We also confirmed that induction of miR-200c to the TKI-resistant cell line resulted in the termination of EMT.
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会议论文
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.
获得的对EGFR抑制剂的耐药性与癌细胞中干细胞样性质的表现有关。
DOI： 10.1158/0008-5472.can-12-4136
发表时间： 2013-05-15
期刊： Cancer research
影响因子： 11.2
作者： [Shien K, Toyooka S, Yamamoto H, Soh J, Jida M, Thu KL, Hashida S, Maki Y, Ichihara E, Asano H, Tsukuda K, Takigawa N, Kiura K, Gazdar AF, Lam WL, Miyoshi S]
通讯作者： Miyoshi S
Biological research for elucidation of molecular mechanisms responsible for thymoma-associated myasthenia gravis
  • 批准号：
    10671259
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $1.92万
  • 财政年份：
    1998
  • 负责人：
    MIYOSHI Shinichiro
  • 依托单位：
    Osaka University
OPTIMUM POTASSIUM CONCENTRATION OF THE PULMONARY PRESERVATION SOLUTION FOR CULTURED PULMONARY ENDOTHELIAL AND SMOOTH MUSCLE CELLS
HOME REHABILITATION FOR PREOPERATIVE THORACOTOMY PATIENTS
  • 批准号：
    06671358
  • 项目类别：
    Grant-in-Aid for General Scientific Research (C)
  • 资助金额：
    $1.34万
  • 财政年份：
    1994
  • 负责人：
    MIYOSHI Shinichiro
  • 依托单位：
    WAKAYAMA MEDICAL COLLEGE
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