The roles of epigenetic mechanism in cerebral ischemic preconditioning

表观遗传机制在脑缺血预处理中的作用

• 批准号: 23592088
• 负责人: YOSHIOKA Hideyuki
• 金额: $ 3.24万
• 依托单位: University of Yamanashi
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592088/
• 关键词: 脳虚血耐性; 虚血性神経細胞傷害; エピジェネティクス; 脳虚血耐性現象

Epigenetic mechanism such as DNA methylation and modifications of histone proteins controls heritable change in gene expression. On the other hand, ischemic preconditioning involves numerous gene expression changes; however, its mechanism is still obscure. In this study, we evaluated the roles of epigenetic mechanism in ischemic preconditioning. Our results show that methylation of histone proteins was modified, and gene expressions related to apoptosis and inflammation were down-regulated in the preconditioned brains. Further studies are necessary to clarify the relationship between epigenetic mechanism and gene expression changes.

表观遗传机制如DNA甲基化和组蛋白修饰控制基因表达的遗传变化。另一方面，缺血预处理涉及大量基因表达变化；然而，其机制仍不清楚。在这项研究中，我们评估了表观遗传机制在缺血预处理中的作用。我们的研究结果表明，在预处理的大脑中，组蛋白的甲基化被修饰，与凋亡和炎症相关的基因表达被下调。表观遗传机制与基因表达变化之间的关系有待进一步研究。