Paho-physiologocal study for moyamoya disease : proteomix and neuroimaging analysis

烟雾病的泛美卫生生理学研究：蛋白质组合和神经影像分析

• 批准号: 23592096
• 负责人: MORIOKA Motohiro
• 金额: $ 3.24万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592096/
• 关键词: もやもや病; MRI; 血管病理; 動脈壁組織; 脳虚血

We studied the arterial pathophysiology of moyamoya disease. We evaluated 3D-CISS MRI studies of 16 patients with MMD, 8 with atherosclerotic middle cerebral artery stenosis, and 27 control subjects. We compared the outside diameter of the intracranial arteries in these 3 groups.The outside diameter of the internal carotid- and the middle cerebral artery (ICA, M1) in the MMD group was significantly smaller than in the other 2 groups (p < 0.05). Furthermore, the outside diameter was unrelated to the progression of internal canal stenosis grade evaluated from digital subtraction angiography.Ours is the first 3D-CISS MRI documentation that in MMD patients, a decrease in the outer diameter of the ICA and M1 precedes the decrease in the inside stenotic change of these vessels. We suggest that changes in the ICA and M1 precede the manifestation of interior pathologial stenosis and may constitute the first step in MMD progression.

我们研究了烟雾病的动脉病理生理学。我们评估了16例MMD患者、8例动脉粥样硬化性大脑中动脉狭窄患者和27例对照者的3D-CISS MRI研究。比较3组颅内动脉的外径，MMD组颈内动脉和大脑中动脉（伊卡，M1）的外径明显小于其他2组（p < 0.05）。此外，外径与数字减影angiography.Ours评估的椎管内狭窄程度的进展无关，这是第一个3D-CISS MRI文件，在MMD患者中，伊卡和M1外径的减少先于这些血管的内部狭窄变化的减少。我们认为伊卡和M1的变化先于内部病理性狭窄的表现，并可能构成MMD进展的第一步。

项目成果

Granulocyte Colony-Stimulating Factor Enhances the Angiogenetic Effect of Indirect Bypass Surgery for Chronic Cerebral Hypoperfusion in a Rat Model

• DOI: 10.1227/neu.0b013e31820c0289
• 发表时间: 2011-05-01
• 期刊: NEUROSURGERY
• 影响因子: 4.8
• 作者: Ohmori, Yuki;Morioka, Motohiro;Kuratsu, Jun-ichi
• 通讯作者: Kuratsu, Jun-ichi

新領域別症候群シリーズ№26 神経症候群（第2版）（I）－その他の神経疾患を含めて－

新区证候系列第26期 神经病证（第2版）（一）-包括其他神经系统疾病-

• 发表时间: 2013
• 作者: 森岡基浩;折戸公彦
• 通讯作者: 折戸公彦

Clinical neuroprotective drugs for treatment and prevention of stroke.

• DOI: 10.3390/ijms13067739
• 发表时间: 2012
• 期刊: International journal of molecular sciences
• 影响因子: 5.6
• 作者: Kikuchi K;Uchikado H;Morioka M;Murai Y;Tanaka E
• 通讯作者: Tanaka E

Anaplastic astrocytomas with abundant Rosenthal fibers in elderly patients: a diagnostic pitfall of high-grade gliomas

老年患者中具有丰富罗森塔尔纤维的间变性星形细胞瘤：高级别胶质瘤的诊断陷阱

• DOI: 10.1111/neup.12025
• 发表时间: 2013
• 期刊: Neuropathology
• 影响因子: 2.3
• 作者: Sugita Y;Nakashima S;Ohshima K;Terasaki M;Morioka M
• 通讯作者: Morioka M