Mechanism of pain generation in the rat model of brachial plexus avulsion and the effect of anti-nerve growth factor receptor (p75 neurotrophin receptor) administration

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In the rat model of brachial plexus avulsion (BPA), pain-related behavior and the extent of glial activation was evaluated. The effect of local and general administration of anti-nerve growth factor receptor (p75 neurotrophin receptor [p75NTR]) antibodies was also evaluated in the BPA model. As a result, rats in the BPA group displayed significant mechanical hyperalgesia in the dermatome innervated by uninjured nerves both ipsilaterally and contra laterally. GFAP-immunoreactive astrocytes and Iba1-immunoreactive microglia were significantly activated on the ipsilateral side in the BPA group. And in the both rats group in which anti-p75NTR was locally or generally, mechanical hyperalgesia was significantly improved. Levels of GFAP-immunoreactive astrocytes and Iba1-immunoreactive microglia in the anti-p75NTR group were significantly reduced.