Development of new joint markers for osteoarthritis

开发骨关节炎的新关节标记物

• 批准号: 23592224
• 负责人: SAITO Tomoyuki
• 金额: $ 3.08万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592224/
• 关键词: 変形性関節症; 関節マーカー; 変形性膝関節症

The purpose of this study is to elucidate pathogenesis of osteoarthritis and to evaluate therapeutic efficacy using joint markers. Clinical status and joint markers were improved by intra-articular injection of hyaluronic acid for patients with osteoarthritis of the knee. Reduction of IL-6 suggests inhibitory effect of hyaluronic acid on inflammation and IL-6 seems to be a novel joint marker to assess progression and therapeutic efficacy for osteoarthritis. Increased number of blood vessels was shown in synovial tissue and increased expressions of angiogenesis-related factors were investigated. These factors contributing to progression of osteoarthritis are also possible joint markers for osteoarthritis.

本研究的目的是阐明骨关节炎的发病机制，并使用关节标志物评估治疗效果。透明质酸关节腔内注射治疗膝关节骨性关节炎可改善患者的临床状况和关节标志物。IL-6的减少表明透明质酸对炎症的抑制作用，IL-6似乎是评估骨关节炎进展和治疗效果的新关节标志物。滑膜组织中血管数量增加，血管生成相关因子表达增加。这些导致骨关节炎进展的因素也可能是骨关节炎的关节标志物。

项目成果

Fractures Around the Lateral Cortical Hinge After a Medial Opening-Wedge High Tibial Osteotomy: A New Classification of Lateral Hinge Fracture

• DOI: 10.1016/j.arthro.2011.06.034
• 发表时间: 2012-01-01
• 期刊: ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
• 影响因子: 4.7
• 作者: Takeuchi, Ryohei;Ishikawa, Hiroyuki;Saito, Tomoyuki
• 通讯作者: Saito, Tomoyuki

専門医のための疾患・外傷診療ガイド変形性膝関節症(特発性骨壊死を含む)

疾病和创伤专家治疗指南膝骨关节炎（包括特发性骨坏死）

• 发表时间: 2012
• 期刊: 関節外科10月増刊号
• 作者: 齋藤知行;熊谷研
• 通讯作者: 熊谷研

Five- to ten-year outcome following medial opening-wedge high tibial osteotomy with rigid plate fixation in combination with an artificial bone substitute

• DOI: 10.1302/0301-620x.96b3.32525
• 发表时间: 2014-03-01
• 期刊: BONE & JOINT JOURNAL
• 影响因子: 4.6
• 作者: Saito, T.;Kumagai, K.;Kusayama, Y.
• 通讯作者: Kusayama, Y.

Mid- term results of stryker® scorpio plus mobile bearing total knee arthroplasty.

• DOI: 10.1186/1758-2555-4-38
• 发表时间: 2012-10-18
• 期刊: Sports medicine, arthroscopy, rehabilitation, therapy & technology : SMARTT
• 作者: Kobayashi H;Mitsugi N;Mochida Y;Taki N;Akamatsu Y;Aratake M;Ota H;Ishii K;Harigane K;Ideno T;Saito T
• 通讯作者: Saito T

変形性膝関節症における十字靱帯の変性は靭帯細胞の軟骨分化に関連する

膝骨关节炎中的十字韧带变性与韧带细胞的软骨分化有关

• 发表时间: 2013
• 作者: 熊谷研,草山喜洋;赤松泰;酒井尚雄,齋藤知行
• 通讯作者: 酒井尚雄,齋藤知行