Analgesic mechanisms of gabapentinoids in spinal cord dorsal horn

我们研究了加巴喷丁类药物（普瑞巴林和加巴喷丁）对脊髓背角谷氨酸能突触传递的影响。采用膜片钳对背根附着的脊髓片背浅角神经元进行全细胞记录。加巴喷丁素不降低背根刺激引起的单突触兴奋性突触电流的振幅。这些结果表明加巴喷丁类药物不抑制谷氨酸从初级传入末端释放。抑制电压门控钙通道可能不是这些加巴喷丁类药物的主要镇痛机制。

We investigated the effects of gabapentinoids (pregabalin and gabapentin) on glutamatergic synaptic transmission in the spinal cord dorsal horn.Whole cell patch clamp recordings were made from superficial dorsal horn neurons of spinal cord slice with attached dorsal root. Gabapentinoids did not decrease the amplitude of monosynaptic excitatory synaptic currents evoked by dorsal root stimulations. These result suggest that gabapentinoids do not inhibit glutamate release from primary afferent terminals. The inhibition of voltage-gated calcium channels may not be a main analgesic mechanism of these gabapentinoid drugs.