A new strategy for adrenal insufficiency in septic shock: a new antioxdant ETS-GS

脓毒性休克肾上腺功能不全的新策略：新型抗氧化剂 ETS-GS

• 批准号: 23592300
• 负责人: MATSUMOTO Shigekiyo
• 金额: $ 3.33万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592300/
• 关键词: 敗血症; 酸化ストレス; ビタミンC; 電子スピン共鳴; 副腎不全; ETS-GS; ビタミン

In the septic rat model administered lipopolysaccharide(LPS), we established the method to measure in real time serum vitamin C levels by using an electron spin resonance spectrometer. Twenty four hours after high dose LPS, serum vitamin C decresed remarkably and the inflammatory response increased.The new antioxidant, ETS-GS which has very strong antiinflammatory and antioxidant effects tended to inhibit serum vitamin C loss and the infllammatory response. The hormones of pituitary and adrenal, however, didn't increase significantly. Therefore, I could not figure out the relationship between the ETS-GS and the hypothalamus-pituitary-adrenal axis.In the future, I will plan to use the SMP30 knockout mouse which cannot synthesize vitamin C like human and continue this study.

在给予脂多糖（LPS）的化粪池模型中，我们通过使用电子自旋谐振光谱仪建立了实时血清维生素C水平测量的方法。高剂量LPS​​后的二十四小时，血清维生素C腐烂明显地增加，炎症反应增加。具有非常强大的抗炎和抗氧化作用的新型抗氧化剂ETS-GS倾向于抑制血清维生素C的损失和芬芳反应。然而，垂体和肾上腺的激素并未显着增加。因此，我无法弄清ETS-GS与下丘脑 - 垂体 - 肾上腺轴之间的关系。未来，我计划使用SMP30敲除小鼠，该小鼠无法像人类那样综合维生素C并继续这项研究。