Expression and Bio-function of Sugar chains in uterine endometrial adenocarcinoma, cervical carcinoma and uterine endometrium

糖链在子宫内膜腺癌、宫颈癌及子宫内膜中的表达及生物学功能

• 批准号: 23592465
• 负责人: MIKAMI Mikio
• 金额: $ 3.33万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592465/
• 关键词: 子宮体癌; 子宮頸癌; 子宮内膜; 卵巣癌; 分化度; 腺腔形成; 糖脂質; 硫酸化糖脂質; 薬剤耐性; バイオマーカー

Carbohydrate chains on cell membranes contributes to the mutal recognition of various cells and cell differentiation, and the structure of carbohydrate chains changes with oncogenesis. In this study, we have clarified that the transfection of sulfotransferase genes to endometrial cancer cells changes the cell characters such as cell morphology and response to the trypsin treatment, and that all the uterine cervical cancer cells express GM2 ganglioside, and that ovarian cancer cells resistant to Paclitaxel strongly express Gb3Cer and ganglioside, and that with analysis of glycopeptides in serum of ovarian cancer patients and healthy women by mass spectrometer, a new biomarker for ovarian cancers was found.

细胞膜上的碳水化合物链有助于各种细胞和细胞分化的突变识别，碳水化合物链的结构随着肿瘤发生而变化。 In this study, we have clarified that the transfection of sulfotransferase genes to endometrial cancer cells changes the cell characters such as cell morphology and response to the trypsin treatment, and that all the uterine cervical cancer cells express GM2 ganglioside, and that ovarian cancer cells resistant to Paclitaxel strongly express Gb3Cer and ganglioside, and that with analysis of glycopeptides in serum of ovarian cancer patients和健康的女性质谱仪是一种新的卵巢癌生物标志物。

项目成果

A case of Metastatic Uterine Cervical Squamous Cell Carcinoma in the Right Atrium

右心房转移性子宫颈鳞状细胞癌1例

• 发表时间: 2013
• 期刊: Tokai J Exp Clin Med
• 作者: Togo A;Muramatsu T;Tsukada H;Ikeda M;Shida M;Hirasawa T;Maeda H and Mikami M
• 通讯作者: Maeda H and Mikami M

OGS NOW No.6

现在OGS No.6

• 发表时间: 2011
• 作者: 三上幹男;他
• 通讯作者: 他

東海大学医学部医学科伊勢原キャンパス

东海大学医学部伊势原校区

婦人科腫瘍における Thymidine phosphorylase の治療マーカーとしての可能性

胸苷磷酸化酶作为妇科肿瘤治疗标志物的潜力

• 发表时间: 2013
• 作者: 信田政子;三上幹男;ほか
• 通讯作者: ほか

ヒト漿液性卵巣癌由来細胞における抗がん剤耐性糖脂質の変化

人浆液性卵巢癌来源细胞中抗癌药物糖脂的变化

• 发表时间: 2011
• 作者: 坂本幸士;樫尾明憲;安井拓也;狩野章太郎;柿木章伸;山岨達也;曽我部万紀;宮澤昌樹;田中京子;Mikami;Y.Goto;宮澤昌樹;田中京子
• 通讯作者: 田中京子