Expression and Bio-function of Sugar chains in uterine endometrial adenocarcinoma, cervical carcinoma and uterine endometrium

糖链在子宫内膜腺癌、宫颈癌及子宫内膜中的表达及生物学功能

• 批准号: 23592465
• 负责人: MIKAMI Mikio
• 金额: $ 3.33万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592465/
• 关键词: 子宮体癌; 子宮頸癌; 子宮内膜; 卵巣癌; 分化度; 腺腔形成; 糖脂質; 硫酸化糖脂質; 薬剤耐性; バイオマーカー

Carbohydrate chains on cell membranes contributes to the mutal recognition of various cells and cell differentiation, and the structure of carbohydrate chains changes with oncogenesis. In this study, we have clarified that the transfection of sulfotransferase genes to endometrial cancer cells changes the cell characters such as cell morphology and response to the trypsin treatment, and that all the uterine cervical cancer cells express GM2 ganglioside, and that ovarian cancer cells resistant to Paclitaxel strongly express Gb3Cer and ganglioside, and that with analysis of glycopeptides in serum of ovarian cancer patients and healthy women by mass spectrometer, a new biomarker for ovarian cancers was found.

细胞膜上的碳水化合物链有助于各种细胞的相互识别和细胞分化，碳水化合物链的结构随着肿瘤的发生而改变。在本研究中，我们明确了将硫转移酶基因转染子宫内膜癌细胞后，改变了细胞形态和对胰蛋白酶治疗的反应等细胞特性，所有子宫癌细胞均表达GM2神经节苷脂，卵巢癌紫杉醇耐药细胞强烈表达Gb3Cer和神经节苷脂，并通过质谱分析卵巢癌患者和健康女性血清中的糖肽类。一种新的卵巢癌生物标志物被发现。

项目成果

Potential impact of combined high- and low-risk human papillomavirus infection on the progression of cervical intraepithelial neoplasia 2

高危和低危人乳头瘤病毒联合感染对宫颈上皮内瘤变进展的潜在影响2

• DOI: 10.1111/jog.12202
• 发表时间: 2014
• 期刊: J Obstet Gynaecol Res
• 作者: Okadome M;Saito T;Tanaka H;Nogawa T;Furuta R;Watanabe K;Kita T;Yamamoto K;Mikami M;Takizawa K
• 通讯作者: Takizawa K

Expression and correlation of Lewis y antigen and TGF-β1 in ovarian epithelial carcinoma.

• DOI: 10.3892/or.2011.1575
• 发表时间: 2012-04
• 期刊: Oncology reports
• 影响因子: 4.2
• 作者: Wang ST;Liu JJ;Wang CZ;Lin B;Hao YY;Wang YF;Gao S;Qi Y;Zhang SL;Iwamori M
• 通讯作者: Iwamori M

Characterization of novel glycolipid antigens with an {alpha}-galactose epitope in lactobacilli detected with rabbit anti-lactobacillus antisera and occurrence of antibodies against them in human sera.

用兔抗乳酸杆菌抗血清检测到的乳酸杆菌中具有 {α}-半乳糖表位的新型糖脂抗原的表征以及人血清中针对它们的抗体的出现。

• 发表时间: 2011
• 期刊: J Biochem
• 影响因子: 2.7
• 作者: Iwamori M;Sakai A;Minamimoto N;Iwamori Y;Tanaka K;Aoki D;Adachi S;Nomura T
• 通讯作者: Nomura T

Enhanced Expression of Sulfatide, a Sulfated Glycolipid, In Uterine Cervical

硫脂苷（一种硫酸化糖脂）在宫颈中的表达增强

• 发表时间: 2013
• 作者: 宮澤昌樹;三上幹男;ほか
• 通讯作者: ほか

レクチンアレイを用いた子宮内膜・子宮体癌(高分化型・低分化型)に発現する糖蛋白糖鎖の検索

使用凝集素阵列寻找子宫内膜癌（高分化型/低分化型）中表达的糖蛋白糖链

• 发表时间: 2011
• 作者: 坂本幸士;樫尾明憲;安井拓也;狩野章太郎;柿木章伸;山岨達也;曽我部万紀;宮澤昌樹;田中京子;Mikami;Y.Goto;宮澤昌樹;田中京子;西島義博
• 通讯作者: 西島義博