Expression and Bio-function of Sugar chains in uterine endometrial adenocarcinoma, cervical carcinoma and uterine endometrium
Expression and Bio-function of Sugar chains in uterine endometrial adenocarcinoma, cervical carcinoma and uterine endometrium
批准号:
23592465
负责人:
MIKAMI Mikio
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013
中文摘要
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英文摘要
Carbohydrate chains on cell membranes contributes to the mutal recognition of various cells and cell differentiation, and the structure of carbohydrate chains changes with oncogenesis. In this study, we have clarified that the transfection of sulfotransferase genes to endometrial cancer cells changes the cell characters such as cell morphology and response to the trypsin treatment, and that all the uterine cervical cancer cells express GM2 ganglioside, and that ovarian cancer cells resistant to Paclitaxel strongly express Gb3Cer and ganglioside, and that with analysis of glycopeptides in serum of ovarian cancer patients and healthy women by mass spectrometer, a new biomarker for ovarian cancers was found.
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Potential impact of combined high- and low-risk human papillomavirus infection on the progression of cervical intraepithelial neoplasia 2
高危和低危人乳头瘤病毒联合感染对宫颈上皮内瘤变进展的潜在影响2
DOI:
10.1111/jog.12202
发表时间:
2014
期刊:
J Obstet Gynaecol Res
影响因子:
--
作者:
[Okadome M, Saito T, Tanaka H, Nogawa T, Furuta R, Watanabe K, Kita T, Yamamoto K, Mikami M, Takizawa K]
通讯作者:
Takizawa K
DOI:
10.3892/or.2011.1575
发表时间:
2012-04
期刊:
Oncology reports
影响因子:
4.2
作者:
[Wang ST, Liu JJ, Wang CZ, Lin B, Hao YY, Wang YF, Gao S, Qi Y, Zhang SL, Iwamori M]
通讯作者:
Iwamori M
Characterization of novel glycolipid antigens with an {alpha}-galactose epitope in lactobacilli detected with rabbit anti-lactobacillus antisera and occurrence of antibodies against them in human sera.
用兔抗乳酸杆菌抗血清检测到的乳酸杆菌中具有 {α}-半乳糖表位的新型糖脂抗原的表征以及人血清中针对它们的抗体的出现。
DOI:
--
发表时间:
2011
期刊:
J Biochem
影响因子:
2.7
作者:
[Iwamori M, Sakai A, Minamimoto N, Iwamori Y, Tanaka K, Aoki D, Adachi S, Nomura T]
通讯作者:
Nomura T
Enhanced Expression of Sulfatide, a Sulfated Glycolipid, In Uterine Cervical
硫脂苷(一种硫酸化糖脂)在宫颈中的表达增强
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[宮澤昌樹, 三上幹男, ほか]
通讯作者:
ほか
レクチンアレイを用いた子宮内膜・子宮体癌(高分化型・低分化型)に発現する糖蛋白糖鎖の検索
使用凝集素阵列寻找子宫内膜癌(高分化型/低分化型)中表达的糖蛋白糖链
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[坂本幸士, 樫尾明憲, 安井拓也, 狩野章太郎, 柿木章伸, 山岨達也, 曽我部万紀, 宮澤昌樹, 田中京子, Mikami, Y.Goto, 宮澤昌樹, 田中京子, 西島義博]
通讯作者:
西島義博
共 65 条
Development of hemodiagnosis for early detection of ovarian cancer using glycopeptide peaks obtained from CSGSA (Comprehensive Serum Glycopeptide Spectra Analysis)
-
批准号:17H04340
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.9万
-
财政年份:2017
-
负责人:MIKAMI Mikio
-
依托单位:
Development of a novel glycoprotein serum biomarker for epithelial ovarian cancer with more superior diagnostic capability than CA125
-
批准号:26462538
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.0万
-
财政年份:2014
-
负责人:MIKAMI Mikio
-
依托单位:
Bio-function of glycolipids in uterine endometrial adencarcinoma and cervical carcinoma, and uterine endometrium
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批准号:20591962
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.83万
-
财政年份:2008
-
负责人:MIKAMI Mikio
-
依托单位:
海外基金