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Expression and Bio-function of Sugar chains in uterine endometrial adenocarcinoma, cervical carcinoma and uterine endometrium

Expression and Bio-function of Sugar chains in uterine endometrial adenocarcinoma, cervical carcinoma and uterine endometrium
糖链在子宫内膜腺癌、宫颈癌及子宫内膜中的表达及生物学功能
批准号:
23592465
负责人:
MIKAMI Mikio
金额:
$3.33万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
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英文摘要
Carbohydrate chains on cell membranes contributes to the mutal recognition of various cells and cell differentiation, and the structure of carbohydrate chains changes with oncogenesis. In this study, we have clarified that the transfection of sulfotransferase genes to endometrial cancer cells changes the cell characters such as cell morphology and response to the trypsin treatment, and that all the uterine cervical cancer cells express GM2 ganglioside, and that ovarian cancer cells resistant to Paclitaxel strongly express Gb3Cer and ganglioside, and that with analysis of glycopeptides in serum of ovarian cancer patients and healthy women by mass spectrometer, a new biomarker for ovarian cancers was found.
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会议论文
Potential impact of combined high- and low-risk human papillomavirus infection on the progression of cervical intraepithelial neoplasia 2
高危和低危人乳头瘤病毒联合感染对宫颈上皮内瘤变进展的潜在影响2
DOI: 10.1111/jog.12202
发表时间: 2014
期刊: J Obstet Gynaecol Res
影响因子: --
作者: [Okadome M, Saito T, Tanaka H, Nogawa T, Furuta R, Watanabe K, Kita T, Yamamoto K, Mikami M, Takizawa K]
通讯作者: Takizawa K
DOI: 10.3892/or.2011.1575
发表时间: 2012-04
期刊: Oncology reports
影响因子: 4.2
作者: [Wang ST, Liu JJ, Wang CZ, Lin B, Hao YY, Wang YF, Gao S, Qi Y, Zhang SL, Iwamori M]
通讯作者: Iwamori M
レクチンアレイを用いた子宮内膜・子宮体癌(高分化型・低分化型)に発現する糖蛋白糖鎖の検索
使用凝集素阵列寻找子宫内膜癌(高分化型/低分化型)中表达的糖蛋白糖链
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [坂本幸士, 樫尾明憲, 安井拓也, 狩野章太郎, 柿木章伸, 山岨達也, 曽我部万紀, 宮澤昌樹, 田中京子, Mikami, Y.Goto, 宮澤昌樹, 田中京子, 西島義博]
通讯作者: 西島義博
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [杉山太朗, 後藤優美子, 西島義博, 平澤 猛, 村松俊成, 石本人士, 和泉俊一郎, 三上幹男]
通讯作者: 三上幹男
65
    Development of hemodiagnosis for early detection of ovarian cancer using glycopeptide peaks obtained from CSGSA (Comprehensive Serum Glycopeptide Spectra Analysis)
    • 批准号:
      17H04340
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.9万
    • 财政年份:
      2017
    • 负责人:
      MIKAMI Mikio
    • 依托单位:
    Development of a novel glycoprotein serum biomarker for epithelial ovarian cancer with more superior diagnostic capability than CA125
    • 批准号:
      26462538
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2014
    • 负责人:
      MIKAMI Mikio
    • 依托单位:
    Bio-function of glycolipids in uterine endometrial adencarcinoma and cervical carcinoma, and uterine endometrium
    • 批准号:
      20591962
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2008
    • 负责人:
      MIKAMI Mikio
    • 依托单位:
    海外基金