Identification of tumor suppressive nucleic acid medicine in maxillary sinus squamous cell carcionma

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Our recent studies of microRNA (miRNA) expression signature of maxillary sinus squamous cell carcinoma (MSSCC) demonstrated that microRNA-874 (miR-874) was significantly downregulated in cancer tissues, suggesting miR-874 function as a tumor suppressor. Restoration of mature miR-874 significantly inhibited cancer cell proliferation and induced apoptosis. Expression data of miR-874 transfectants and in silico analysis demonstrated that histone deacetylase 1 (HDAC1) was a direct target of miR-874 regulation. Silencing of the HDAC1 gene significantly inhibited cell proliferation and induced G2/M arrest and cell apoptosis in cancer cell. Downregulation of miR-874 was a frequent event in HNSCC. miR-874 acted as a tumor suppressor and directly targeted HDAC1. Recognition of tumor-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of MSSCC oncogenesis and suggests novel therapeutic strategies for the disease.