Usefulness of the nasal nitric oxide density in the diagnosis treatment of allergic rhinitis

鼻腔一氧化氮密度在过敏性鼻炎诊断和治疗中的作用

• 批准号: 23592507
• 负责人: YAMAMOTO HIDEYUKI
• 金额: $ 3.33万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592507/
• 关键词: 鼻腔一酸化窒素濃度; アレルギー性鼻炎; 臨床試験; NO合成酵素; 遺伝子多型; スギ花粉症; 鼻腔一酸化窒素; NO; 鼻腔一酸化窒素濃度 (nNO); NOx-; 鼻腔一酸化窒素濃度（nNO）

We compared the levels of nasal nitric oxide (nNO) between patients with seasonal allergic rhinitis of Japanese cedar pollen (SAR-JCP) and people with non SAR-JCP during JCP season. The levels of nNO in SAR-JCP groups were significantly higher than that of non SAR-JCP group. In the patient with SAR-JCP, symptom score was positively correlated with the levels of nNO, significantly. To evaluate the effect of anti-allergic medicine on levels of nNO in the patient with SAR-JCP, nNO was measured in patients with SAR-JCP before and after administration of anti-allergic medicine, olopatadine. We could not find any differences in levels of nNO between before and after administration of olopatadine.We also observed the effect of nasal surgery on the levels of nNO in the patient with perennial allergic rhinitis (PAR). Nasal surgery (submucosal conchotomy and posterior nerve resection) significantly decreased the levels of nNO.

我们比较了日本雪松花粉季节性变应性鼻炎（SAR-JCP）患者和非SAR-JCP患者在JCP季节的鼻一氧化氮（nNO）水平。SAR-JCP组nNO水平显著高于非SAR-JCP组。SAR-JCP患者的症状积分与nNO水平呈正相关。为了评价抗过敏药物对SAR-JCP患者nNO水平的影响，检测了SAR-JCP患者使用抗过敏药物奥洛他定前后的nNO水平。我们还观察了鼻手术对常年性变应性鼻炎（PAR）患者nNO水平的影响。鼻手术（粘膜下鼻甲切开术和后神经切除术）显著降低nNO水平。

项目成果

Efficacy of the co-administration of montelukast and loratadine for seasonal allergic rhinitis

孟鲁司特与氯雷他定联合用药治疗季节性过敏性鼻炎的疗效

• 发表时间: 2012
• 作者: H.Yamamoto;S.Fujieda;T.Yamada;S.Kubo;M.Sakasita;D.Susuki;T.Morikawa
• 通讯作者: T.Morikawa

Efficacy of prophylactic treatment with montelukast and montelukast plus add-on loratadine for seasonal allergic rhinitis

• DOI: 10.2500/aap.2012.33.3514
• 发表时间: 2012-03-01
• 期刊: ALLERGY AND ASTHMA PROCEEDINGS
• 影响因子: 2.8
• 作者: Yamamoto, Hideyuki;Yamada, Takechiyo;Fujieda, Shigeharu
• 通讯作者: Fujieda, Shigeharu

スギ花粉症患者における第２世代抗ヒスタミン薬と抗ロイコトリエン薬併用療法の検討

第二代抗组胺药与抗白三烯药物联合治疗柳杉花粉过敏患者的疗效观察

• 作者: Kondo K;Kanaya K;Suzukawa K;Kikuta S;Sakamoto T;Yamasoba T;山本 英之
• 通讯作者: 山本 英之

スギ花粉症患者の治療 医師主導型臨床試験によるEBMの確立

雪松花粉病患者的治疗：通过医生主导的临床试验建立 EBM

• 作者: 岩村均;近藤健二;坂本幸士;菊田周;鈴川佳吾;金谷佳織;山岨達也;児玉悟;山本 英之
• 通讯作者: 山本 英之

Efficacy of mometasone furoate nasal spray for nasal symptoms, quality of life, rhinitis-disturbed sleep, and nasal nitric oxide in patients with perennial allergic rhinitis.

糠酸莫米松鼻喷雾剂对常年性过敏性鼻炎患者鼻部症状、生活质量、鼻炎干扰睡眠和鼻一氧化氮的疗效。

• DOI: 10.2500/aap.2012.33.3509
• 发表时间: 2012
• 期刊: Allergy and asthma proceedings
• 影响因子: 2.8
• 作者: Takechiyo Yamada;Hideyuki Yamamoto;Seita Kubo;M. Sakashita;Takahiro Tokunaga;D. Susuki;N. Narita;K. Ogi;Masafumi Kanno;Shinji Yamashita;Yuko Terasawa;Y. Kayano;M. Masada;S. Fujieda
• 通讯作者: S. Fujieda