Effect of Transcutaneous immunotherapy in Allergic Rhinitis

皮下过敏原特异性免疫疗法是治疗IgE介导的过敏症的有效方法，但它需要反复注射过敏原，有发生全身过敏反应的风险。经皮免疫治疗可提高患者的依从性和安全性。我们的第一个目的是研究经皮免疫治疗在变应性鼻炎中的作用。同时，我们还研究了细胞因子处理的鼻息肉成纤维细胞中TSLP的表达。鼻息肉成纤维细胞能够在肿瘤坏死因子α刺激下产生TSLP。联合应用肿瘤坏死因子-α、Th2细胞因子(IL-4)对鼻息肉成纤维细胞产生TSLP有协同作用。干扰素-γ可强烈抑制TSLP的产生，而IL-10对其无明显抑制作用。

Subcutaneous allergen-specific immunotherapy is an effective treatment of IgE-mediated allergies, but it requires repeated allergen injections with a risk of systemic allergic reactions. Transcutaneous immunotherapy may improve patient compliance and safety. Our first aim is to investigate the effect of transcutaneous immunotherapy in Allergic Rhinitis.And also, we investigated the expression of TSLP in cytokine-treated nasal polyp fibroblasts. Nasal polyp fibroblasts have the capacity to produce TSLP in response to stimulation by tumor necrosis factor (TNF) alpha. Combined stimulation with TNF-alpha a Th2 cytokine (IL-4) was synergistic for TSLP production by the nasal polyp fibroblasts. TSLP production was strongly inhibited by interferon gamma but not by IL-10.