Fundamental study evidencing relationship between tonsillar focal diseases and palatine tonsils

证明扁桃体病灶与腭扁桃体关系的基础研究

• 批准号: 23592518
• 负责人: TAKAHARA Miki
• 金额: $ 3.24万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592518/
• 关键词: 扁桃病巣疾患; IgA腎症; APRIL; CXCR3; 咽頭科学; 口蓋扁桃

IgA nephropathy (IgAN) has a poor prognosis because of progress to end-stage renal failure over a period of 20 years. IgAN is famous for typical tonsillar focal diseases, and tonsillectomy has been reported to be effective for inhibition of the progression. Unfortunately, this fact was not widely known. We try to establish fundamental relationship between IgAN and palatine tonsils by immunological technique in order to enlighten other doctors about the effectiveness of tonsillectomy and clarify a factor which predict the effectiveness.In this serious of examination, we found that APRIL(a proliferation-inducing ligand) was involved in hyper-production of IgA from the tonsils of IgAN patients, and that chemokine receptor CXCR3 on tonsillar T-cells was related to homing of T-cells to the lesions of glomerulus. These results indicate that tonsils are related to not only abnormality of IgA, but also T-cell homing. We will continue to study for further understanding of the relationships.

IGA肾病（IGAN）的预后不佳，因为在20年内终端肾衰竭的进展。 Igan以典型的扁桃体局部疾病而闻名，据报道，扁桃体切除术可有效抑制进展。不幸的是，这一事实并不广为人知。 We try to establish fundamental relationship between IgAN and palatine tonsils by immunological technique in order to enlighten other doctors about the effectiveness of tonsillectomy and clarify a factor which predict the effectiveness.In this serious of examination, we found that APRIL(a proliferation-inducing ligand) was involved in hyper-production of IgA from the tonsils of IgAN patients, and that chemokine receptor CXCR3 on tonsillar T细胞与肾小球病变的T细胞有关。这些结果表明，扁桃体不仅与IgA异常有关，而且与T细胞归巢有关。我们将继续研究以进一步了解关系。

项目成果

「扁桃病巣感染症研究の最前線」 IgA腎症扁桃におけるIgA過剰産生とT細胞の関与

“扁桃体局灶性感染研究的前沿” IgA 过量产生和 T 细胞参与 IgA 肾病扁桃体

• 发表时间: 2011
• 期刊: 口腔咽頭科
• 作者: 坂下智博;本間明宏;折舘伸彦;鈴木清護;畠山博充他;市村恵一;高原 幹
• 通讯作者: 高原 幹

扁桃の免疫機能と病態扁桃を中心としたIgA腎症の病態解明

扁桃体的免疫功能和病理 阐明以扁桃体为中心的 IgA 肾病的病理

• 发表时间: 2011
• 期刊: 小児耳鼻咽喉科
• 作者: Shiga K;Ogawa T;Maki A;Amano M;Kobayashi T.;Takahara M;高原幹
• 通讯作者: 高原幹

Clinical outcome of tonsillectomy for palmoplantar pustulosis and etiological relationship between palmoplantar pustulosis and tonsils

扁桃体切除术治疗掌跖脓疱病的临床效果及掌跖脓疱病与扁桃体的病因关系

• DOI: 10.1159/000324618
• 发表时间: 2011
• 期刊: Adv Otorhinolaryngol
• 作者: Shiga K;Ogawa T;Maki A;Amano M;Kobayashi T.;Takahara M
• 通讯作者: Takahara M

ENT臨床フロンティア のどの異常とプライマリケア 扁桃摘出術の適応は変わったか？

耳鼻喉科临床前沿：扁桃体切除术的哪些异常和初级保健适应症发生了变化？

• 发表时间: 2013
• 作者: Inoue D;Suzuki T;Mitsuishi Y;Miki Y;Suzuki S;Sugawara S;Watanabe M;Sakurada A;Endo C;Uruno A;Sasano H;Nakagawa T;Satoh K;Tanaka N;Kubo H;Motohashi H;Yamamoto M;高原 幹
• 通讯作者: 高原 幹

「耳鼻咽喉科における病巣感染症up date-扁桃・副鼻腔疾患を中心に-」扁桃病巣疾患に対する扁桃摘出術の適応と効果

《耳鼻喉科局灶性感染最新进展——关注扁桃体和鼻窦疾病——》扁桃体切除术治疗局灶性扁桃体疾病的适应症和效果

• 发表时间: 2012
• 期刊: ENTONI
• 作者: 高原幹;原渕保明
• 通讯作者: 原渕保明