The influence of unfolded protein response on age related macular degeneration.

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Death of retinal pigment epitheial cells (RPE) and expression of vascular endotherial growth factor (VEGF) is the cause of age related macular degeneration (AMD). We have studied the influence of unfolded protein response (UPR) to these. When UPR occur in RPE, there was increase of factors that cause apopthosis. We have made lasere induced choroidal neovasularization (CNV) model mice, and comfermed that we could measure the size of CNV. The mice was oraly treated by drug which prevent UPR, however we could not detect the prevention of CNV.Druzen is a precursor of AMD, and Amyloid beta is a component of the druzen. As amyloid beta cause expression of VEGF in RPE cells, we have bought caveolin 1 knockout mice which is known to cause amyloid beta deposit in the brain. We have found old mothers doesn't feed the babies, and need of the young mothers to increase the colony.