The development of new treatments for the flap survial and wound healing using fibrocyte or relevant stem cells.

我们建立了两种新的动物模型：小鼠下肢淋巴水肿模型和大鼠下肢缺血模型。在淋巴水肿模型中，我们用脂肪源性干细胞移植证实淋巴水肿模型中淋巴管再生。在肢体缺血模型中，我们证实了血液循环的改善。我们发现脂肪来源的干细胞和皮瓣联合移植可以进一步改善血液循环。我们认为这两种新的动物模型可用于开发使用各种干细胞和药物的新疗法。

We have developed two new animal models of a lower extremity lymphedema mouse model and a lower extremity limb ischemia rat model. In the lymphedema model we confirmed regeneration of lymphatic vessels in the lymphedema model using adipose-derived stem cell transplantation. In the limb ischemia model we confirmed the improvement of blood circulation. We found to further improve blood circulation using combined adipose-derived stem cells and flap transplantation.We think our two new animal models are available for the development of novel therapies using various stem cells and drug agents.