Hippo signaling pathway regulates proliferation and ECM production in cancer cells

Hippo信号通路通过诱导yes相关蛋白（YAP）的磷酸化和细胞质保留来抑制YAP的转录共激活活性。在本研究中，我们发现Hippo和tgf - β通路在调节结缔组织生长因子（CTGF）方面存在功能相互作用。恶性肿瘤细胞中CTGF的表达是通过在CTGF启动子上形成YAP/TEAD4/Smad3/p300复合物来诱导的。我们的数据表明，CTGF是肿瘤细胞生长的重要调节剂。

Hippo signaling pathway inhibits the transcriptional coactivation activity of Yes-associated protein (YAP) by inducing phosphorylation and cytoplasmic retention of YAP. In this study, we have found a functional interaction between the Hippo and TGF-beta pathways in regulating connective tissue growth factor (CTGF). Expression of CTGF in malignant tumor cells was induced by the formation of a YAP/TEAD4/Smad3/p300 complex on the CTGF promoter. Our data suggest that CTGF is an important modulator of tumor cell growth.