Development of dual induction therapy for the regulation of chronic inflammation and hard tissue formation of dental pulp and periapical tissues

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To develop dual induction therapy for the regulation of chronic inflammation and hard tissue formation of dental pulp and periapical tissues, we focused on effects of newly developed cement on several cells, effects of steroid coactivator MTI-II on osteoblasts, effects of PRP and BMP-2 on odontoblasts, and effects of ameloblastin on epithelial cells. We found that the biocompatibility of newly developed cement, effects of BMP-2 on odontoblast differentiation, the suppression of epithelial cell proliferation by ameloblastin, the regulation of inflammatory responses of osteoblasts by MTI-II, and the induction of odontoblast differentiation related molecules by PRP.