Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa

点击翻译按钮获取中文摘要

Mesenchymal stem cells (MSCs) are an attractive cell source in regenerative medicine because of their multi-differentiation capacity and regulatory functions, specifically at sites of inflammation. Here, we investigated the effect of systemic MSC transplantation on peri-implant epithelial sealing. MSCs were systemically injected into recipient rats via the tail vein. The injected MSCs accumulated at the injured gingival mucosa, following which the oral epithelium closed and peri-implant epithelium (PIE) formed from the oral sulcular epithelium earlier than in control rats. Furthermore, in the MSC-implant group, a laminin 332 (Ln)-positive layer was detected along the interface of the PIE-implant at 4 weeks. Conversely, Ln was only observed in the apical region and connective tissue region in the control group. Systemic MSC transplantation may be effective for enhancing epithelial sealing around titanium implants.