Therapeutic Interaction of Systemically-administered Mesenchymal Stem Cells with Peri-implant Mucosa

系统施用的间充质干细胞与种植体周围粘膜的治疗相互作用

• 批准号: 23592888
• 负责人: ATSUTA Ikiru
• 金额: $ 3.33万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592888/
• 关键词: インプラント; 幹細胞; 上皮封鎖; 間葉系幹細胞; インプラント周囲上皮; インプラント周囲炎; 細胞治療; 国際研究者交流; ニッチ; 生体材料（チタン）

Mesenchymal stem cells (MSCs) are an attractive cell source in regenerative medicine because of their multi-differentiation capacity and regulatory functions, specifically at sites of inflammation. Here, we investigated the effect of systemic MSC transplantation on peri-implant epithelial sealing. MSCs were systemically injected into recipient rats via the tail vein. The injected MSCs accumulated at the injured gingival mucosa, following which the oral epithelium closed and peri-implant epithelium (PIE) formed from the oral sulcular epithelium earlier than in control rats. Furthermore, in the MSC-implant group, a laminin 332 (Ln)-positive layer was detected along the interface of the PIE-implant at 4 weeks. Conversely, Ln was only observed in the apical region and connective tissue region in the control group. Systemic MSC transplantation may be effective for enhancing epithelial sealing around titanium implants.

间充质干细胞(MSCs)具有多向分化能力和调节功能，尤其是在炎症部位，是再生医学中极具吸引力的细胞来源。在这里，我们研究了系统间充质干细胞移植对种植体周围上皮封闭的影响。将MSCs经尾静脉系统注射到受体大鼠体内。移植的MSCs在损伤的牙龈黏膜处聚集，随后口腔上皮关闭，种植体周上皮(PIE)早于对照组形成。此外，在MSC-种植体组，在第4周时，在PIE-种植体的界面上检测到层粘连蛋白332(Ln)阳性层。相反，对照组仅在根尖区和结缔组织区可见Ln。系统间充质干细胞移植可能有效地增强钛种植体周围的上皮封闭性。

项目成果

Technetium-99 conjugated with methylene diphosphonate ameliorates ovariectomy-induced osteoporotic phenotype without causing osteonecrosis in the jaw.

• DOI: 10.1007/s00223-012-9649-7
• 发表时间: 2012-12
• 期刊: CALCIFIED TISSUE INTERNATIONAL
• 影响因子: 4.2
• 作者: Zhao, Yinghua;Wang, Lei;Liu, Yi;Akiyama, Kentaro;Chen, Chider;Atsuta, Ikiru;Zhou, Tao;Duan, Xiaohong;Jin, Yan;Shi, Songtao
• 通讯作者: Shi, Songtao

The role of phosphoinositide 3-kinase in adhesion of oral epithelial cells to titanium

• DOI: 10.1016/j.archoralbio.2013.07.013
• 发表时间: 2013-11-01
• 期刊: ARCHIVES OF ORAL BIOLOGY
• 影响因子: 3
• 作者: Atsuta, Ikiru;Ayukawa, Yasunori;Koyano, Kiyoshi
• 通讯作者: Koyano, Kiyoshi

インプラント表面性状の違いがラット口腔粘膜上皮に与える影響

种植体表面特性差异对大鼠口腔粘膜上皮的影响

• 发表时间: 2012
• 作者: 熱田生;鮎川保則;古橋明大;荻野洋一郎;森山泰子;築山能大;古谷野潔
• 通讯作者: 古谷野潔

Expression of Integrin beta-4 and alpha-3 subunits on the process of peri-implant epithelium formation

整合素β4和α3亚基在种植体周围上皮形成过程中的表达

• 发表时间: 2013
• 期刊: Key Engineering Materials
• 作者: Atsuta I;Ayukawa Y;Yamaza T;Furuhashi A;Kondo R;Moriyama Y;Tsukiyama Y;Koyano K.
• 通讯作者: Koyano K.

IL-17-mediated M1/M2 macrophage alteration contributes to pathogenesis of bisphosphonate-related osteonecrosis of the jaws.

• DOI: 10.1158/1078-0432.ccr-13-0042
• 发表时间: 2013-06-15
• 期刊: Clinical cancer research : an official journal of the American Association for Cancer Research
• 作者: Zhang Q;Atsuta I;Liu S;Chen C;Shi S;Shi S;Le AD
• 通讯作者: Le AD