Investigation of the chronic pain mechanism in the maxillofacial area using index of CRH gene expression in hypothalamus

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Recently, patients having chronic pain in the maxillofacial region, atypical odontalgia and glossodynia are increasing, and this becomes a social problem. However, it is not clear the mechanism of chronic pain and method of treatment. The aim of this study is diagnosis of stress of pain and correct therapy. We considered that the pain is one of impression as stressor, and analyzed the influence of the stress on the hypothalamus-pituitary-adrenal(HPA) axis and paraventricular hypothalamic nucleus(PVN). In this study, we inject the solution of capsaicin at the tip of the rat tongue that is controlled by the mandibular nerve branched from the trigeminal nerve, and clear the change in PVN by acute pain stress and following nerve injury.It is provided that the c-fos gene transcription which is a neuronal exciting marker is increasing in both the hypothalamic PVN and the trigeminal ganglion.