Nicotine promote bone resorption through the vascular endothelial cells

在这项研究中，使用人静脉内皮细胞来检查尼古丁是否在体外调节促进骨吸收的细胞因子的产生。尼古丁可抑制人脐静脉内皮细胞护骨素基因的表达。相反，尼古丁促进核因子kappa-B配体受体激活物的mRNA表达，从而促进人脐静脉内皮细胞的骨吸收。这些结果提供了基础知识，有力地表明吸烟是牙周病的危险因素。

In this study used human vein endothelial cells to examine whether nicotine regulated production of cytokines which promoted bone resorption in vitro. Nicotine inhibited the mRNA expression of osteoprotegerin in the HUVEC. In contrast, nicotine promoted the mRNA expression receptor activator of nuclear factor kappa-B ligand to promote bone resorption from the HUVEC. These results provide fundamental knowledge that indicates strongly that smoking is a risk factor for periodontal disease.