Influence of Illumination During Mydriasis for Fundus Examination on Stress Response in Premature Infants : Analysis of Saliva, Behavior, and Heart Rate Variability

眼底检查时散瞳时照明对早产儿应激反应的影响：唾液、行为和心率变异性分析

• 批准号: 23593344
• 负责人: HORIGANE Yukie
• 金额: $ 3.58万
• 依托单位: International University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23593344/
• 关键词: 早産児; 光環境; ストレス; 唾液クロモグラニンA; 自律神経活動; 早産児行動評価; 光; 唾液分析; 自律神経; 行動評価; 自律神経活動評価; コルチゾール; 心拍変動解析

Objective:This study aimed to evaluate the influence of low and normal illumination during fundus examination on the stress response in premature infants through the evaluation of saliva, behavior, and autonomic nervous activity reflected by heart rate variability.Methods: A total of 36 premature infants who were born at an average gestational age of 29.4 weeks (25.2 weeks-34.6 weeks) with an average birth weight of 1,296 g (727-2,146 g) were included in this study. All infants underwent fundus examination with the induction of mydriasis under normal illumination(control group) or low illumination (intervention group), and salivary chromogranin A levels, behavior, and heart rate variability were analyzed before and until 6 hours after the induction of mydriasis.Results: The mean salivary chromogranin A levels were significantly lower(40.51 +- 40.796 pmol/mg) in the intervention group than in the control group in (167.72 +- 84.634pmol/mg ; p < .05; t-test).

目的：通过评价心率变异性所反映的唾液、行为和自主神经活动，评价眼底检查低照度和正常照度对早产儿应激反应的影响。方法：36例早产儿出生，平均胎龄29.4周(25.2周~34.6周)，平均出生体重1296 g(727~2146 g)。结果：干预组患儿的唾液嗜铬粒蛋白A水平(167.72±84.634pmol/mg；p&lt；0.05；t检验)明显低于对照组(P<0.05)。

项目成果

光環境に対する超早産児のストレス反応―行動観察による散瞳時と非散瞳時の比較―

极早产儿对光环境的应激反应——基于行为观察的散瞳与不散瞳病例比较——

• 作者: 堀内成子;石井慶子;太田尚子;蛭田明子;堀内祥子;有森直子;蛭田明子;石井慶子;石井慶子;蛭田明子;石井慶子;蛭田 明子;蛭田 明子;太田尚子，蛭田明子，北園真希，勝又里織;堀金幸栄
• 通讯作者: 堀金幸栄

光環境に対する超早産児のストレス反応―唾液コルチゾールを用いた散瞳時と非散瞳時の比較―

极早产儿对光环境的应激反应 - 使用唾液皮质醇对散瞳和非散瞳病例进行比较 -

• 作者: 堀内成子;石井慶子;太田尚子;蛭田明子;堀内祥子;有森直子;蛭田明子;石井慶子;石井慶子;蛭田明子;石井慶子;蛭田 明子;蛭田 明子;太田尚子，蛭田明子，北園真希，勝又里織;堀金幸栄;堀金幸栄
• 通讯作者: 堀金幸栄