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The basic research on oral environment of community-acquired pneumonia prevention in a local community elderly

当地社区老年人口腔环境预防社区获得性肺炎的基础研究

基本信息

批准号：
23593457
负责人：
KUMAZAWA YUKI
金额：
$ 3.24万
依托单位：
Aichi Prefectural University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2011
资助国家：
日本
起止时间：
2011 至 2013
项目状态：
已结题

项目摘要

We clarified the saliva protein concentrations (secretory immunoglobulin A: sIgA; lactoferrin: LF; epidermal growth factor: EGF) which controlled to intraoral bacteria, and Streptococcus pneumoniae carrying germs for a normal adults and a local community elderly, as a basic research for the community-acquired pneumonia prevention. And we examined the association of a concentration of saliva protein with age, Streptococcus pneumoniae carrying germs and pneumococcus vaccination.An adult group was the highest in the ratio of Streptococcus pneumoniae carriers (55.6%). The concentrations of sIgA, LF, EGF were higher in the adult group than the older adult and old-old groups. No association was found between the pneumococcus vaccination factor and the sIgA concentration. As for non-carrying and carrying group among the elderly, non-carrying were higher than those carrying in sIgA, LF (old-old group), and EGF concentration.

明确了控制口腔内细菌的分泌型免疫球蛋白A：SIgA；乳铁蛋白：Lf；表皮生长因子：EGF；肺炎链球菌携带细菌的唾液蛋白浓度，作为社区获得性肺炎预防的基础研究。我们还研究了唾液蛋白浓度与年龄、肺炎链球菌携带细菌和接种肺炎球菌疫苗的关系。成人组肺炎链球菌携带者的比例最高(55.6%)。成年组SIgA、Lf、EGF水平高于老年组和老年组。肺炎球菌疫苗接种因子和SIgA浓度之间没有发现关联。老年非携带组和携带组的SIgA、LF值、EGF浓度均高于携带组。