Clinical research on the central nervous system disorder by quantitative determination of serum tryptophan metabolites

苯环利定治疗的精神分裂症动物模型小鼠脑组织（伏隔核和海马）中l -色氨酸（L-Trp）浓度显著降低。这一结果表明，左旋色氨酸代谢失调发生在这些脑区。在本研究中，观察到显著的性别差异，即男性健康受试者血清中的l -色氨酸浓度高于女性健康受试者。l -色氨酸和L-KYN浓度在男性中有显著相关性，而在女性中无显著相关性。血清中l -色氨酸、KYN和5-羟色胺水平在对照组和精神分裂症患者之间存在显著差异，提示血清中l -色氨酸、KYN和5-羟色胺的测定可能对临床诊断至关重要。

In the brain tissue (nucleus accumbens and hippocampus) of phencyclidine-treated mice which is an animal model of schizophrenia, the L-tryptophan (L-Trp)concentration was significantly decreased. This result suggested that dysregulation of L-Trp metabolism occurred in these brain regions.In the present study, a significant gender difference was observed, namely, L-Trp concentration in the sera of male healthy subjects was higher than that of female healthy subjects. A significant correlation was observed between L-Trp and L-KYN concentrations in male, but not in female subjects. The serum levels of L-Trp, KYN, and serotonin were significantly different between controls and schizophrenia patients, suggesting that determinations of L-Trp, KYN, and 5-HT in serum might be crucial for clinical diagnosis.