Clinical research on the central nervous system disorder by quantitative determination of serum tryptophan metabolites

在作为精神分裂症动物模型的苯环己哌啶处理小鼠的脑组织（脑髓核和海马）中，L-色氨酸（L-Trp）浓度显著降低。结果表明，L-Trp代谢异常发生在这些脑区。在本研究中，观察到了显著的性别差异，即男性健康受试者血清中L-Trp浓度高于女性健康受试者。在男性受试者中观察到L-Trp和L-KYN浓度之间存在显著相关性，但在女性受试者中未观察到。对照组与精神分裂症患者血清L-Trp、KYN和5-HT水平差异有统计学意义，提示血清L-Trp、KYN和5-HT水平的测定对精神分裂症的诊断有重要意义。

In the brain tissue (nucleus accumbens and hippocampus) of phencyclidine-treated mice which is an animal model of schizophrenia, the L-tryptophan (L-Trp)concentration was significantly decreased. This result suggested that dysregulation of L-Trp metabolism occurred in these brain regions.In the present study, a significant gender difference was observed, namely, L-Trp concentration in the sera of male healthy subjects was higher than that of female healthy subjects. A significant correlation was observed between L-Trp and L-KYN concentrations in male, but not in female subjects. The serum levels of L-Trp, KYN, and serotonin were significantly different between controls and schizophrenia patients, suggesting that determinations of L-Trp, KYN, and 5-HT in serum might be crucial for clinical diagnosis.