Establishment of suitable diet plan focusing on liver fat for prevention of lifestyle-related disease and health promotion

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We investigated to establish suitable diet plan for Japanese obese subjects with metabolic syndrome (METS) to prevent lifestyle-related disease and contribute to health promotion. To evaluate effect of diet on body fat composition, we performed 1H-MRS and whole abdominal CT-scanning by 700-800 slices for quantitative measurement of liver fat content and abdominal visceral and subcutaneous fat volume, respectively. In results, total energy of 28 kcal/ideal body weight kg, and nutritional balance of carbohydrate 50-55 %, fat 25-30 %, and protein 15-20 % was reduced liver fat by 56 % and visceral fat volume and abdominal subcutaneous fat volume equally by 22 %, and improved clinical parameters such as blood pressure, plasma glucose and lipids, or HOMA-R. Furthermore, throughout this diet period for 1 year, no case of drop out or showing rebound of body eight was observed. Consequently, this diet plan is recommendable to Japanese subjects with obese and METS subjects.