Establishment of suitable diet plan focusing on liver fat for prevention of lifestyle-related disease and health promotion

本研究旨在为患有代谢综合征（METS）的日本肥胖受试者制定合适的饮食计划，以预防生活方式相关疾病并促进健康。 为了评价饮食对体脂组成的影响，我们分别进行了1H-MRS和全腹部CT扫描，扫描层数为700-800层，定量测量肝脏脂肪含量和腹部内脏及皮下脂肪体积。 结果，28 kcal/理想体重kg的总能量，以及碳水化合物50- 55%、脂肪25- 30%和蛋白质15- 20%的营养平衡，使肝脏脂肪减少56%，内脏脂肪体积和腹部皮下脂肪体积相等地减少22%，并改善临床参数，如血压、血糖和血脂或HOMA-R。 此外，在1年的整个饮食期间，没有观察到脱落或显示身体8反弹的情况。 因此，该饮食计划适用于日本肥胖受试者和METS受试者。

We investigated to establish suitable diet plan for Japanese obese subjects with metabolic syndrome (METS) to prevent lifestyle-related disease and contribute to health promotion. To evaluate effect of diet on body fat composition, we performed 1H-MRS and whole abdominal CT-scanning by 700-800 slices for quantitative measurement of liver fat content and abdominal visceral and subcutaneous fat volume, respectively. In results, total energy of 28 kcal/ideal body weight kg, and nutritional balance of carbohydrate 50-55 %, fat 25-30 %, and protein 15-20 % was reduced liver fat by 56 % and visceral fat volume and abdominal subcutaneous fat volume equally by 22 %, and improved clinical parameters such as blood pressure, plasma glucose and lipids, or HOMA-R. Furthermore, throughout this diet period for 1 year, no case of drop out or showing rebound of body eight was observed. Consequently, this diet plan is recommendable to Japanese subjects with obese and METS subjects.