Molecular analyses of genes related to cognitive abilities.
与认知能力相关的基因的分子分析。
基本信息
- 批准号:23650136
- 负责人:
- 金额:$ 2.58万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Challenging Exploratory Research
- 财政年份:2011
- 资助国家:日本
- 起止时间:2011 至 无数据
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
We divided the inbred mice into high and low performance groups by behavioral analysis, and we identified some gene sets that showed differential expression between the groups. Using monozygotic twins discordant for IQ scores, we also identified some gene sets that expressed differentially between siblings and one gene that showed differential DNA methylation status. In patients with mental retardation, we detected several known duplication or deletion syndromes and unknown copy number changes, CNVs. These genes and CNVs could be associated with cognitive abilities.
我们通过行为分析将近交小鼠分为高和低性能组,并确定了一些基因组,这些基因表显示了两组之间的差异表达。使用单卵双胞胎对智商分数不一致,我们还鉴定了一些基因组,这些基因集在兄弟姐妹之间差异表达,一个基因和一个显示出差异DNA甲基化状态的基因。在患有智力低下的患者中,我们检测到几种已知的重复或缺失综合征和未知的拷贝数变化CNV。这些基因和CNV可能与认知能力有关。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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KOBAYASHI Kazuhiro其他文献
KOBAYASHI Kazuhiro的其他文献
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{{ truncateString('KOBAYASHI Kazuhiro', 18)}}的其他基金
Heterocycle synthesis utilizing ortho-fuctionalized benzyl azides
利用邻位官能化苄基叠氮化物合成杂环
- 批准号:
26410051 - 财政年份:2014
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Identifying the genetic basis and understanding the molecular mechanisms underlying cognitive function
识别遗传基础并了解认知功能背后的分子机制
- 批准号:
24300104 - 财政年份:2012
- 资助金额:
$ 2.58万 - 项目类别:
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Heterocycle synthesis utilizing ortho-functionalized phenyl isothiocyanates
利用邻位官能化异硫氰酸苯酯合成杂环
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22550035 - 财政年份:2010
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$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Container ship network design method by multi-commodity flow model
多商品流模型的集装箱船网络设计方法
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21710164 - 财政年份:2009
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Elucidation of molecular pathogenesis and development of treatment for muscular dystrophy and neurodevelopmental disorder caused by abnormal glycosylation
糖基化异常引起的肌营养不良和神经发育障碍的分子发病机制阐明及治疗进展
- 批准号:
21689030 - 财政年份:2009
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Young Scientists (A)
Clarification of mechanism for tritiated water vapor on the meterial surface
澄清金属表面氚化水蒸气的机理
- 批准号:
19760604 - 财政年份:2007
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Development of new, simple and general synthetic methods of useful heterocyclic compounds
开发有用杂环化合物的新的、简单的和通用的合成方法
- 批准号:
15550092 - 财政年份:2003
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Molecular analysis of Fukuyama muscular dystrophy and functional analysis of the gene product fukutin.
福山性肌营养不良症的分子分析及基因产物fukutin的功能分析。
- 批准号:
13672376 - 财政年份:2001
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of simple methods for the preparation of heterocycle-fused quinones and their application to the synthesis of natural products
杂环稠合醌的简单制备方法的开发及其在天然产物合成中的应用
- 批准号:
10650852 - 财政年份:1998
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development and Application of New Transformations of Organosulfur Compounds Utilizing Magnesium Amides
氨基镁有机硫化合物新转化的开发与应用
- 批准号:
07651032 - 财政年份:1995
- 资助金额:
$ 2.58万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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