Molecular analyses of genes related to cognitive abilities.

与认知能力相关的基因的分子分析。

• 批准号: 23650136
• 负责人: KOBAYASHI Kazuhiro
• 金额: $ 2.58万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650136/
• 关键词: 脳認知科学; ゲノム脳科学; エピジェネティクス; 認知; 知能; 精神発達遅滞; CNV; マイクロアレイ

We divided the inbred mice into high and low performance groups by behavioral analysis, and we identified some gene sets that showed differential expression between the groups. Using monozygotic twins discordant for IQ scores, we also identified some gene sets that expressed differentially between siblings and one gene that showed differential DNA methylation status. In patients with mental retardation, we detected several known duplication or deletion syndromes and unknown copy number changes, CNVs. These genes and CNVs could be associated with cognitive abilities.

我们通过行为分析将近交系小鼠分为高性能组和低性能组，并确定了一些在组之间表现出差异表达的基因集。使用智商不一致的同卵双胞胎，我们还鉴定了一些在兄弟姐妹之间差异表达的基因集，以及一个显示不同DNA甲基化状态的基因。在智力低下患者中，我们发现了几种已知的复制或缺失综合征和未知的拷贝数变化，CNV。这些基因和CNV可能与认知能力有关。

项目成果

Genome-wide DNA methylation and gene expression analyses of monozygotic twins discordant for intelligence levels.

• DOI: 10.1371/journal.pone.0047081
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Yu CC;Furukawa M;Kobayashi K;Shikishima C;Cha PC;Sese J;Sugawara H;Iwamoto K;Kato T;Ando J;Toda T
• 通讯作者: Toda T