Microglial subtypes: Identification and characterization of their roles in emotional functions

虽然hoxb8谱系的小胶质细胞被认为与强迫症谱系障碍有关，但小胶质细胞与情绪调节之间的证据很少。在本项目中，我发现克隆的小胶质细胞和部分骨髓祖细胞表达Hoxb8。将这些细胞直接注射到纹状体中，可以改善被迫游泳的应激小鼠的应激脆弱性。这些结果表明，小胶质细胞可能参与大脑高级功能的压力调节。

Although Hoxb8-lineage microglia are indicated to be involved in the obsessive-compulsive disorder spectrum disorder, there are few lines of evidence between microglia and emotional regulation. In this project I indicated that cloned microglia and a part of bone marrow progenitorcells expressed Hoxb8. Injection of these cells directly into striatum improved stress-vulnerability in the forced-swimming stressed mice. These results suggest that microglia may be involved in stress-regulation of higher brain functions.