Role of MITOL in mitochondrial function and oxidative stress signaling

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We previously identified a novel mitochondrial ubiquitin ligase called MITOL. MITOL has been shown to control mitochondrial dynamics by regulating mitochondrial fission factors such as Drp1 (EMBO J 2006). In this research project, we found that MITOL protects neuronal cells from mitochondrial damage caused by accumulation of MAP1B-light chain 1 (PNAS 2012). Therefore, MITOL is involved in mitochondrial dynamics, mitochondrial quality control, and protection against oxidative stress. Most recently, we foundthat MITOL regulates E R-mitochondria interaction by controlling Mfn2 activity (Mol Cell 2013). These results suggest that MITOL plays a critical role in mitochondrial regulation and oxidative signaling. Further investigations may shed light on new protective role of MITOL against oxidative stresses