Measurement of platelet activation process on shear blood flows and modeling of thrombus formation process

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In this investigation, thrombus formation process is modeled as three step process, which are activation of platelet, transport of activated platelet and adhesion of platlet to the wall and polymerization. Especially, the dependency of shear rate on the platelet activation was focused in this project. From this project, it is concluded that(1) By working averaged shear rate from 100 to 200 (1/s), thrombus can be found at the wall, and the higher the shear rate becomes, the more thrombus formation rate increases(2) By observation of luminescence with aequorin for detecting platelet-activation, the amplitude of luminescence is too low level comparing with background (SIN ratio) even if changing optical settina up.