Measurement of platelet activation process on shear blood flows and modeling of thrombus formation process

剪切血流下血小板活化过程的测量和血栓形成过程的建模

• 批准号: 23650268
• 负责人: TAMAGAWA Masaaki
• 金额: $ 2.41万
• 依托单位: Kyushu Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650268/
• 关键词: バイオメカニクス; 医用流体機械; 血栓; せん断流れ; 可視化; 血液流れ; 血小板活性化; 医用流体機器

In this investigation, thrombus formation process is modeled as three step process, which are activation of platelet, transport of activated platelet and adhesion of platlet to the wall and polymerization. Especially, the dependency of shear rate on the platelet activation was focused in this project. From this project, it is concluded that(1) By working averaged shear rate from 100 to 200 (1/s), thrombus can be found at the wall, and the higher the shear rate becomes, the more thrombus formation rate increases(2) By observation of luminescence with aequorin for detecting platelet-activation, the amplitude of luminescence is too low level comparing with background (SIN ratio) even if changing optical settina up.

本研究将血栓形成过程模拟为血小板活化、活化血小板转运、血小板粘附和聚合三个步骤。特别是，剪切速率对血小板活化的依赖性是本项目的重点。通过本课题的研究，得出以下结论：（1）在100 ~ 200（1/s）的平均剪切速率下，可以在血管壁处发现血栓，并且剪切速率越高，血栓形成率越高;（2）通过观察水母发光蛋白的发光来检测血小板活化，即使改变光学设置，发光的幅度与背景（SIN比）相比也太低。

项目成果

Effects of high shear rate on thrombus formation process on pipe orifice flows

高剪切速率对血栓形成过程对管道孔口流量的影响

• 发表时间: 2011
• 期刊: Proceedings of the IMECE2011 (ASME 2011 International Mechanical Engineering Congress & Exposition)
• 作者: Masaaki TAMAGAWA;Ryoji MORIYA
• 通讯作者: Ryoji MORIYA

Effects of Shear Rate on Thrombus Formation Rate on Pipe Orifice Flows using Laser Sheet Visualization Method

使用激光片可视化方法研究剪切速率对管孔流中血栓形成速率的影响

• 发表时间: 2012
• 作者: Masaaki Tamagawa;Ryosuke Motooka
• 通讯作者: Ryosuke Motooka

Effects of shear rate on thrombus formation rate on pipe orifice flows

剪切速率对管道孔口流量上血栓形成速率的影响

• 发表时间: 2012
• 期刊: Proceedings of the 8th KSME-JSME Thermal and Fluids Engineering Conference
• 作者: Masaaki Tamagawa;Ryoji Moriya;Ryosuke Motooka
• 通讯作者: Ryosuke Motooka

気泡と衝撃波・放電の相互作用を用いたバラスト水処理システムの開発

利用气泡、冲击波和放电相互作用开发压载水处理系统

• 发表时间: 2012
• 期刊: 日本機械学会論文集（B 編） ノート
• 作者: Morita;S.-i.;Takanezawa;S.;Date;A.;Watanabe;S.;Murakami;T. N.;Kawashima;N.;Sato;H.;and Sako;Y;玉川雅章，猪原哲，古巻圭一
• 通讯作者: 玉川雅章，猪原哲，古巻圭一

Effects of High Shear Rate on Thrombus Formation Rate on Pipe Orifice Flows using Laser Sheet Method and the Prediction of Thrombus Formation Rate by CFD

利用激光片法研究高剪切速率对管道孔口流量血栓形成率的影响以及利用 CFD 预测血栓形成率

• 发表时间: 2012
• 期刊: Proceedings of the IMECE2012 (ASME 2012 International Mechanical Engineering Congress & Exposition)
• 作者: Kanako Tohyama;Kumiko Ishikawa;Shinsaku Maruta;Masaaki Tamagawa
• 通讯作者: Masaaki Tamagawa