Analysis of the mechanism for efficient rehabilitation using cell signaling mutant cells

本研究利用细胞信号转导突变细胞促进神经再生，提高康复效率，旨在从分子水平阐明康复机制，建立脑梗塞后瘫痪的康复方法。在实验中，我们使用了三个新开发的细胞信号突变细胞系，发现(1)热疗等康复刺激通过作用于细胞信号通路中的p38激酶来促进神经再生，(2)乙酰胆碱，它可以改善脑梗塞引起的偏瘫，在相同的信号通路中激活EFK酶，以及(3)Akt酶对神经元的长期生存起作用。

In this study, we carried out experiments using cell signaling mutant cells to improve nerve regeneration and efficiency of rehabilitation with the aims of elucidating the mechanism of rehabilitation at the molecular level and establishing a method for recovery of paralysis due to cerebral infarction. In the experiments, we used three newly developed cell signaling mutant cell lines and found that (1) rehabilitation stimulus by, for example, thermotherapy, promotes nerve regeneration by acting p38 kinase in the cell signaling pathway, (2) acetylcholine, which acts to improve hemiplegia caused by cerebral infarction, activates EFK enzyme in the same signaling pathway, and (3) Akt enzyme functions for long-term survival of neurons.