Regulation of new colon tumor suppressor gene by food componets

食品成分对新结肠抑癌基因的调控

• 批准号: 23650470
• 负责人: ITAGAKI SHIRO
• 金额: $ 2.33万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650470/
• 关键词: 大腸がん; バイオマーカー; 抗がん剤感受性試験; 大腸癌; SLC5A8; 食品機能成分; 短鎖脂肪酸; 食物繊維

Although we could not found the knowledge about regulation of new colon tumor suppressor gene by food components, there were failed. The action in the event that the research does not progress as originally planned, we tried to discovery of biomarkers for prediction of anticancer drug sensitivity using a incubation medium of the anticancer drug sensitivity test. 5-FU is a key drug for the chemotherapy in colon cancer patients. In the term of this study, we did only 3 cases of histoculture drug response assay (HDRA) for colon cancer patient. All of these cases, colon cancer tissue expresses 5-FU sensitivity. Furthter study are needed to found plasma biomarkers of 5-FU sensitivity in chemotherapy.

虽然目前还没有发现食物成分对新的结肠抑癌基因调控的相关知识，但也有失败的报道。如果研究未按原计划进行，我们尝试使用抗癌药物敏感性试验的孵育培养基发现用于预测抗癌药物敏感性的生物标志物。5-FU是结肠癌化疗的关键药物。本研究期间，我们仅对3例结肠癌患者进行了组织培养药物反应试验（HDRA）。所有这些病例中，结肠癌组织表达5-FU敏感性。对5-FU化疗敏感性的血浆生物标志物的研究尚需进一步深入。