Inflammatory responses and cancer initiated by Wnt signal network

Wnt信号网络引发的炎症反应和癌症

• 批准号: 23650594
• 负责人: KIKUCHI Akira
• 金额: $ 2.58万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650594/
• 关键词: Wnt; 炎症; がん; 転移; 抗体療法; Wntシグナル; Wnt5a; 腸管炎症; DSS; LPS; IL-6; IκB; NFκB

Chronic inflammation in microenvironment has been shown to be involved in cancer. This study examined regulation of inflammatory responses by Wnt signaling, which play important roles in cancer pathogenesis. Wnt5 enhanced LPS-dependent IL-6 expression in mouse peritoneal macrophages and the inflammatory responses were reduced in macrophages prepared from Wnt5a knockout mice. The addition of dextran sodium sulfate(DSS) generated a mouse model for bowel inflammatory diseases. Wnt5a knockout mice were resistant to DSS-induced inflammation. Taken together with the observations that expression of Wnt5a is involved in aggressiveness of cancer, these results suggest that Wnt5a signaling links between inflammation and cancer.

微环境中的慢性炎症已被证明与癌症有关。这项研究检查了Wnt信号传导对炎症反应的调节，这些信号在癌症发病机理中起着重要作用。 Wnt5在小鼠腹膜巨噬细胞中增强了LPS依赖性IL-6的表达，并且在Wnt5a敲除小鼠制备的巨噬细胞中降低了炎症反应。脱氧硫酸钠（DSS）的添加产生了用于肠炎性疾病的小鼠模型。 Wnt5a敲除小鼠对DSS诱导的炎症有抵抗力。总之，WNT5A的表达参与癌症的侵袭性，这些结果表明WNT5A信号传导与炎症与癌症之间存在联系。

项目成果

Wnt5a deficiency ameliorates the dextran sulfate sodium(DSS)-induced acute colitis

Wnt5a 缺乏可改善葡聚糖硫酸钠 (DSS) 诱导的急性结肠炎

• 发表时间: 2011
• 作者: Sato;A.;Shojima;K.;Koyama;H.;Kikuchi;A.
• 通讯作者: A.

Growth factor-dependent regulation of cell polarity during tubulogenesis

肾小管发生过程中细胞极性的生长因子依赖性调节

• 发表时间: 2011
• 作者: Kikuchi;A
• 通讯作者: A

Waif1/5T4 inhibits Wnt/□-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization

Waif1/5T4 通过修饰 LRP6 亚细胞定位抑制 Wnt/□-catenin 信号传导并激活非经典 Wnt 通路

• 发表时间: 2011
• 期刊: Dev.Cell.
• 作者: Kagermeier-Schenk;B.;et.al.
• 通讯作者: et.al.

its signaling and implication in tumorigenesis

其信号传导及其在肿瘤发生中的意义

• 发表时间: 2011
• 作者: Kikuchi;A.、Wnt5a
• 通讯作者: A.、Wnt5a

翻訳後修飾によるWnt蛋白質の機能発現の制御

通过翻译后修饰控制 Wnt 蛋白的功能表达

• 发表时间: 2011
• 作者: 山本英樹;粟田ちひろ;高尾敏文;岸田昭世;岸田想子;菊池章
• 通讯作者: 菊池章