Inflammatory responses and cancer initiated by Wnt signal network

微环境中的慢性炎症已被证明与癌症有关。这项研究考察了Wnt信号对炎症反应的调节，这在癌症的发病机制中发挥了重要作用。Wnt5增强小鼠腹腔巨噬细胞内毒素依赖的IL-6的表达，而Wnt5a基因敲除小鼠制备的巨噬细胞的炎症反应被降低。添加葡聚糖硫酸钠(DSS)建立了肠道炎症性疾病的小鼠模型。Wnt5A基因敲除小鼠对DSS诱导的炎症具有抵抗力。综上所述，Wnt5a的表达与癌症的侵袭性有关，这些结果表明Wnt5a信号转导与炎症和癌症之间存在联系。

Chronic inflammation in microenvironment has been shown to be involved in cancer. This study examined regulation of inflammatory responses by Wnt signaling, which play important roles in cancer pathogenesis. Wnt5 enhanced LPS-dependent IL-6 expression in mouse peritoneal macrophages and the inflammatory responses were reduced in macrophages prepared from Wnt5a knockout mice. The addition of dextran sodium sulfate(DSS) generated a mouse model for bowel inflammatory diseases. Wnt5a knockout mice were resistant to DSS-induced inflammation. Taken together with the observations that expression of Wnt5a is involved in aggressiveness of cancer, these results suggest that Wnt5a signaling links between inflammation and cancer.