Inflammatory responses and cancer initiated by Wnt signal network

Wnt信号网络引发的炎症反应和癌症

• 批准号: 23650594
• 负责人: KIKUCHI Akira
• 金额: $ 2.58万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650594/
• 关键词: Wnt; 炎症; がん; 転移; 抗体療法; Wntシグナル; Wnt5a; 腸管炎症; DSS; LPS; IL-6; IκB; NFκB

Chronic inflammation in microenvironment has been shown to be involved in cancer. This study examined regulation of inflammatory responses by Wnt signaling, which play important roles in cancer pathogenesis. Wnt5 enhanced LPS-dependent IL-6 expression in mouse peritoneal macrophages and the inflammatory responses were reduced in macrophages prepared from Wnt5a knockout mice. The addition of dextran sodium sulfate(DSS) generated a mouse model for bowel inflammatory diseases. Wnt5a knockout mice were resistant to DSS-induced inflammation. Taken together with the observations that expression of Wnt5a is involved in aggressiveness of cancer, these results suggest that Wnt5a signaling links between inflammation and cancer.

微环境中的慢性炎症已被证明与癌症有关。这项研究考察了Wnt信号对炎症反应的调节，这在癌症的发病机制中发挥了重要作用。Wnt5增强小鼠腹腔巨噬细胞内毒素依赖的IL-6的表达，而Wnt5a基因敲除小鼠制备的巨噬细胞的炎症反应被降低。添加葡聚糖硫酸钠(DSS)建立了肠道炎症性疾病的小鼠模型。Wnt5A基因敲除小鼠对DSS诱导的炎症具有抵抗力。综上所述，Wnt5a的表达与癌症的侵袭性有关，这些结果表明Wnt5a信号转导与炎症和癌症之间存在联系。

项目成果

Wnt5a deficiency ameliorates the dextran sulfate sodium(DSS)-induced acute colitis

Wnt5a 缺乏可改善葡聚糖硫酸钠 (DSS) 诱导的急性结肠炎

• 发表时间: 2011
• 作者: Sato;A.;Shojima;K.;Koyama;H.;Kikuchi;A.
• 通讯作者: A.

Growth factor-dependent regulation of cell polarity during tubulogenesis

肾小管发生过程中细胞极性的生长因子依赖性调节

• 发表时间: 2011
• 作者: Kikuchi;A
• 通讯作者: A

The transmembrane protein Waif1/ 5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization

跨膜蛋白 Waif1/ 5T4 通过修改 LRP6 亚细胞定位抑制 Wnt/β-catenin 信号传导并激活非经典 Wnt 通路

• 发表时间: 2011
• 期刊: Dev. Cell
• 作者: Kagermeier-Schenk;B.;Wehner;D.;Ozhan-Kizil;G.;Yamamoto;H.;Jian Li;Kirchner;K.;Hoffmann;C.;Stern;P.;Kikuchi;A.;Schambony;A.;and Weidinger;G
• 通讯作者: G

Wnt5a ; its signaling and implication in tumorigenesis

Wnt5a ;

• 发表时间: 2011
• 作者: Kikuchi;A.;et.al.
• 通讯作者: et.al.

The Dvl-associating protein Daple controls Rac activation and cell migration

Dvl 相关蛋白 Daple 控制 Rac 激活和细胞迁移

• 发表时间: 2011
• 作者: Ishida;M.;Enomoto;A.;Kikuchi;A.;Takahashi;M.
• 通讯作者: M.