Regulation of signaling network and cellular responses by Wnt

Wnt 调节信号网络和细胞反应

• 批准号: 21249017
• 负责人: KIKUCHI Akira
• 金额: $ 30.7万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21249017/
• 关键词: Wnt; シグナル伝達; 受容体; エンドサイトーシス; 極性; がん; 転移; ヘパラン硫酸プロテオグリカン; グリピカン; β-カテニン依存性経路; β-カテニン非依存性経路; エクトドメイン; Wnt5a; Dvl; 細胞分裂期; 前立腺癌; MMP; 紡錘糸; Dkkl; 接着斑; インテグリン; リピッドラフト; クラスリン

In this study we analyzed the molecular mechanism of the regulation of Wnt signaling and the pathogenesis of diseases due to its abnormalities. The following points were clarified.(1) The selective activation of Wnt signaling was regulated by receptor-mediated endocytosis.(2) Wnt5a regulated cell migration through the organization of microtubule stability by the binding of Dvl and APC.(3) Overexpression of Wnt5a promoted aggressiveness of gastric cancer through the induction of laminin 2.

在本研究中，我们分析了Wnt信号调节的分子机制及其异常引起的疾病的发病机制。阐明了以下几点：(1)Wnt信号的选择性激活是通过受体介导的内吞作用来调节的。(2)Wnt5a通过Dvl和APC的结合来组织微管稳定性来调节细胞迁移。(3)Wnt5a的过表达通过诱导层粘连蛋白2促进胃癌的侵袭性。

项目成果

Wnt5a : its signaling, functions, and implication in diseases

Wnt5a：其信号传导、功能和在疾病中的意义

• 发表时间: 2012
• 期刊: Acta physiol
• 影响因子: 6.3
• 作者: Kikuchi;A.;Yamamoto;H.;Sato;A.;and Maysimoto;S
• 通讯作者: S

Wntシグナルによる上皮形態形成制御とその異常による病態

Wnt信号及其异常引起的病理状况对上皮形态发生的控制

• 发表时间: 2011
• 作者: Miyata T;Harakuni T;Tsuboi T.;他6名;菊池章
• 通讯作者: 菊池章

Wnt 5 a regulates distinct signaling pathways by binding to Frizzled 2

• 发表时间: 2009
• 作者: A. Sato;Hideki Yamamoto;H. Sakane;H. Koyama;A. Kikuchi

LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

• DOI: 10.1242/jcs.058008
• 发表时间: 2010-02-01
• 期刊: JOURNAL OF CELL SCIENCE
• 影响因子: 4
• 作者: Sakane, Hiroshi;Yamamoto, Hideki;Kikuchi, Akira
• 通讯作者: Kikuchi, Akira

Wnt-Ryk Signaling Mediates Axon Growth Inhibition and Limits Functional Recovery after Spinal Cord Injury

• DOI: 10.1089/neu.2008.0776
• 发表时间: 2009-07-01
• 期刊: JOURNAL OF NEUROTRAUMA
• 影响因子: 4.2
• 作者: Miyashita, Tomohiro;Koda, Masao;Yamashita, Toshihide
• 通讯作者: Yamashita, Toshihide