A novel study to identify DNA determinants that generate the meiotic recombination hotspots

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We explored characteristics of the physical properties and conformations of DSB (double-strand break) hotspots on the genomes of yeasts (Saccharomyces cerevisiae and Schizosaccharomyces pombe) and mouse (Mus musculus). When averaged, DSB hotspots of each organism clearly showed a distinctive mechanical property compared to the surrounding regions. However, very interestingly, the properties themselves were opposite between the yeasts and mouse: i.e., DSB hotspots are very rigid in the former while very flexible in the latter. Another physical property to be noted was that DSB hotspots of all the three organisms show distinctively high duplex disruption energy compared to the surrounding regions.