Synthesis and Application of Unnatural Chiral Amino acids and Peptides

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To develop the novel field of amino acid chemistry, we focused on the synthesis of chiral amino acids and peptides having dynamic chirality or a silicon stereocenter. We accomplished the synthesis of dynamic planar chiral amino acids and peptides having an orthocyclophane skeleton. Furthermore, we successfully developed a catalytic enantioselective approach to chiral alkenylhydrosilanes, which are potential chiral building blocks for chiral amino acids having a silicon stereocenter.